Gaur Meenakshi, Dobke Marek, Lunyak Victoria V
Aelan Cell Technology, San Francisco, CA 94107, USA.
Division of Plastic Surgery, University of California, San Diego, La Jolla, CA 92121, USA.
Int J Mol Sci. 2017 Jan 20;18(1):208. doi: 10.3390/ijms18010208.
Operating at multiple levels of control, mesenchymal stem cells from adipose tissue (ADSCs) communicate with organ systems to adjust immune response, provide signals for differentiation, migration, enzymatic reactions, and to equilibrate the regenerative demands of balanced tissue homeostasis. The identification of the mechanisms by which ADSCs accomplish these functions for dermatological rejuvenation and wound healing has great potential to identify novel targets for the treatment of disorders and combat aging. Herein, we review new insights into the role of adipose-derived stem cells in the maintenance of dermal and epidermal homeostasis, and recent advances in clinical applications of ADSCs related to dermatology.
来自脂肪组织的间充质干细胞（ADSCs）在多个控制层面发挥作用，与器官系统进行通信以调节免疫反应，为细胞分化、迁移、酶促反应提供信号，并平衡组织内稳态的再生需求。识别ADSCs实现这些皮肤年轻化和伤口愈合功能的机制，对于确定治疗疾病和对抗衰老的新靶点具有巨大潜力。在此，我们综述了脂肪源性干细胞在维持真皮和表皮内稳态中的作用的新见解，以及ADSCs在皮肤科临床应用方面的最新进展。
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