Am J Gastroenterol. 2010 Dec;105(12):2693-6. doi: 10.1038/ajg.2010.396.
Increasing evidence accumulates for a role of environmental factors in the onset of inflammatory bowel diseases (IBD). Among them, factors that might disturb the gut microflora hold an important place. As such, antibiotics deserve a special attention, and a possible association between their use, particularly during childhood, and the development of IBD, has been assessed by several authors since 1987. Results, conclusions, and possible impact of their observations, as well as perspectives for the future, are discussed here, in view of the article published in this issue of the Journal by Shaw et al.
越来越多的证据表明环境因素在炎症性肠病（IBD）的发病中起作用。其中，可能扰乱肠道微生物群的因素占有重要地位。因此，抗生素值得特别关注，自 1987 年以来，已有几位作者评估了抗生素的使用（特别是在儿童时期）与 IBD 发展之间的可能关联。鉴于 Shaw 等人在本期杂志上发表的文章，本文讨论了这些观察结果的结果、结论和可能的影响，以及未来的展望。
