Department of Orthopedic, The 2nd Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin, 150086 Heilongjiang, China.
Mol Biol Rep. 2011 Oct;38(7):4793-6. doi: 10.1007/s11033-010-0620-2. Epub 2010 Dec 5.
The association between apolipoprotein E (APOE) epsilon 4 (ε4) allele and outcomes of traumatic spinal cord injury (SCI) is still controversial and ambiguous. The objective of this study was to test the hypothesis that APOE polymorphisms are associated with outcomes after SCI in Chinese Han patients. APOE polymorphisms were determined in 100 patients with cervical SCI (C3-C8). The genotype frequency of this polymorphism was determined by using a polymerase chain reaction-restriction fragment length polymorphism assay. Patients with an APOE ε4 allele had significantly less motor recovery during rehabilitation than did patients without an APOE ε4 allele (mean 3.7 vs. 6.1; P = 0.04) and a longer rehabilitation length of stay (LOS) (mean 117.4 vs. 94.5; P = 0.02), but better sensory-pinprick recovery (mean 6.1 vs. 4.0; P = 0.03). There were no significant differences by APOE ε4 allele status in sensory-light touch recovery or acute LOS. This study suggests that the APOE ε4 allele is associated with outcomes after SCI and longer rehabilitation LOS in Chinese Han patients.
载脂蛋白 E (APOE) ɛ4 (ε4) 等位基因与创伤性脊髓损伤 (SCI) 结局的关系仍存在争议和不明确。本研究旨在检验 APOE 多态性与中国汉族患者 SCI 后结局相关的假设。100 例颈段 SCI (C3-C8) 患者检测 APOE 多态性。通过聚合酶链反应-限制性片段长度多态性分析确定该多态性的基因型频率。携带 APOE ε4 等位基因的患者在康复期间的运动功能恢复明显不如不携带 APOE ε4 等位基因的患者（平均 3.7 分比 6.1 分；P=0.04），康复住院时间也更长（平均 117.4 天比 94.5 天；P=0.02），但感觉-刺痛恢复更好（平均 6.1 分比 4.0 分；P=0.03）。APOE ε4 等位基因状态对感觉-轻触恢复或急性 LOS 无显著差异。本研究提示 APOE ε4 等位基因与中国汉族患者 SCI 后结局和康复住院时间延长相关。
