Kayal Sibnath, Ramanujan Raju Vijayaraghavan
School of Materials Science and Engineering, Nanyang Technological University, 639798, Singapore.
J Nanosci Nanotechnol. 2010 Sep;10(9):5527-39. doi: 10.1166/jnn.2010.2461.
Magnetic drug targeting, using core-shell magnetic carrier particles loaded with anti-cancer drugs, is an emerging and significant method of cancer treatment. Gold shell-iron core nanoparticles (Fe@Au) were synthesized by the reverse micelle method with aqueous reactants, surfactant, co-surfactant and oil phase. XRD, XPS, TEM and magnetic property measurements were utilized to characterize these core-shell nanoparticles. Magnetic measurements showed that the particles were superparamagnetic at room temperature and that the saturation magnetization decreased with increasing gold concentration. The anti-cancer drug doxorubicin (DOX) was loaded onto these Fe@Au nanoparticle carriers and the drug release profiles showed that upto 25% of adsorbed drug was released in 80 h. It was found that the amine (-NH2) group of DOX binds to the gold shell. An in vitro apparatus simulating the human circulatory system was used to determine the retention of these nanoparticle carriers when exposed to an external magnetic field. A high percentage of magnetic carriers could be retained for physiologically relevant flow speeds of fluid. The present findings show that DOX loaded gold coated iron nanoparticles are promising for magnetically targeted drug delivery.
磁性药物靶向技术是一种新兴且重要的癌症治疗方法，它利用负载抗癌药物的核壳磁性载体颗粒。采用反向微乳液法，以水性反应物、表面活性剂、助表面活性剂和油相合成了金壳-铁芯纳米颗粒（Fe@Au）。利用X射线衍射（XRD）、X射线光电子能谱（XPS）、透射电子显微镜（TEM）和磁性测量对这些核壳纳米颗粒进行了表征。磁性测量表明，这些颗粒在室温下具有超顺磁性，并且饱和磁化强度随金浓度的增加而降低。将抗癌药物阿霉素（DOX）负载到这些Fe@Au纳米颗粒载体上，药物释放曲线表明，在80小时内高达25%的吸附药物被释放。研究发现，DOX的胺基（-NH2）与金壳结合。使用模拟人体循环系统的体外装置来确定这些纳米颗粒载体在暴露于外部磁场时的滞留情况。对于生理相关的流体流速，可以保留高比例的磁性载体。目前的研究结果表明，负载DOX的金包被铁纳米颗粒在磁性靶向药物递送方面具有前景。
