Nelson Andrew J D, Thur Karen E, Marsden Charles A, Cassaday Helen J
School of Psychology, University of Nottingham, Nottingham, England.
Behav Neurosci. 2010 Dec;124(6):789-99. doi: 10.1037/a0021114.
There is increasing focus on the role of the nucleus accumbens (NAc) in learning and memory, but there is little consensus as to how the core and medial shell subregions of the NAc contribute to these processes. In the current experiments, we used spontaneous object recognition to test rats with 6-hydroxydopamine lesions targeted at the core or medial shell of the NAc on a familiarity discrimination task and a location discrimination task. In the object recognition variant, control animals were able to discriminate the novel object at both 24-hr and 5-min delay. However, in the lesion groups, performance was systematically related to dopamine (DA) levels in the core but not the shell. In the location recognition task, sham-operated animals readily detected the object displacement at test. In the lesion groups, performance impairment was systematically related to DA levels in the shell but not the core. These results suggest that dopamine function within distinct subregions of the NAc plays dissociable roles in the modulation of memory for objects and place.
伏隔核（NAc）在学习和记忆中的作用日益受到关注，但对于NAc的核心和内侧壳亚区如何促进这些过程，人们几乎没有达成共识。在当前实验中，我们使用自发物体识别来测试经6-羟基多巴胺损伤靶向NAc核心或内侧壳的大鼠在熟悉度辨别任务和位置辨别任务中的表现。在物体识别变体中，对照动物在24小时和5分钟延迟时都能够辨别新物体。然而，在损伤组中，表现与核心而非壳中的多巴胺（DA）水平存在系统性关联。在位置识别任务中，假手术动物在测试时很容易检测到物体位移。在损伤组中，表现受损与壳而非核心中的DA水平存在系统性关联。这些结果表明，NAc不同亚区内的多巴胺功能在物体和位置记忆的调节中发挥着不同的作用。
