Srivatanakul Petcharin, Honjo Satoshi, Kittiwatanachot Pacharin, Jedpiyawongse Adisorn, Khuhaprema Thiravud, Miwa Masanao
National Cancer Institute, Rajchathewi, Bangkok, Thailand.
Asian Pac J Cancer Prev. 2010;11(4):985-8.
Liver cancer is the most common cancer in males in Thailand and the third in females. A high incidence of cholangiocarcinoma (CCA) is estimated in the northeast of Thailand. Chronic infection with Opisthorchis viverrini (OV) is the major risk factor for development of CCA. It has been demonstrated that HCV infection is a risk factor for CCA in non - endemic area of OV infection. We examined the association of HBV and HCV and risk of CCA in the northeast Thailand. All cases of CCA were recruited between 1999 and 2001 from Nakhon Phanom provincial hospital and all community hospitals in the province. One control per case was selected, matched by sex, age (∓5 years) and residence. 106 case-control pairs were obtained. Anti-OV, HBsAg, and Anti HCV were determined by ELISA. Among 103 age-sex-place of residence matched case-control pairs, there were 7, 0, 0, 96 pairs for anti-HCV (+) case vs. (-) control, (+) case vs. (+) control, (-) case vs. (+) control and (-) case vs. (-) control combinations (OR=7/0). Among 106 matched pairs, there were 9, 2, 4, 91 pairs for the similar four combinations of HBsAg (OR=2.25 (95%CI: 0.63-10.0). If the subject had anti-HCV and/or HBsAg, the OR for CCA was 4.00 (95%CI: 1.29-16.4). Even after adjustment for anti-OV, risk for HBsAg and/or anti-HCV positive was still marginally increased with an OR of 4.69 although not reaching statistical significance (95%CI: 0.98-22.5). Hepatitis B and C virus infection may also play role in the development of CCA in northeast Thailand.
肝癌是泰国男性中最常见的癌症，在女性中排第三。据估计，泰国东北部胆管癌（CCA）的发病率很高。华支睾吸虫（OV）的慢性感染是CCA发生的主要危险因素。已证明，在OV感染的非流行地区，丙型肝炎病毒（HCV）感染是CCA的一个危险因素。我们研究了泰国东北部HBV和HCV与CCA风险的关联。1999年至2001年期间，从廊开府省医院和该省所有社区医院招募了所有CCA病例。每个病例选择一名对照，按性别、年龄（±5岁）和居住地进行匹配。共获得106对病例对照。采用酶联免疫吸附测定法（ELISA）检测抗OV、乙肝表面抗原（HBsAg）和抗HCV。在103对年龄-性别-居住地匹配的病例对照中，抗HCV（+）病例与（-）对照、（+）病例与（+）对照、（-）病例与（+）对照以及（-）病例与（-）对照组合分别有7、0、0、96对（比值比[OR]=7/0）。在106对匹配对中，HBsAg的类似四种组合分别有9、2、4、91对（OR=2.25[95%置信区间（CI）：0.63 - 10.0]）。如果受试者有抗HCV和/或HBsAg，CCA的OR为4.00（95%CI：1.29 - 16.4）。即使在调整抗OV后，HBsAg和/或抗HCV阳性的风险仍略有增加，OR为4.69，尽管未达到统计学显著性（95%CI：0.98 - 22.5）。乙肝和丙肝病毒感染在泰国东北部CCA的发生中可能也起作用。
