Barusrux Sahapat, Nanok Chaiyachet, Puthisawas Watcharapong, Pairojkul Chawalit, Poovorawan Yong
Department of Clinical Immunology and Transfusion Medicine, Centre for Research and Development of Medical Diagnostic Laboratories, Khon Kaen University, Khon Kaen, Thailand.
Asian Pac J Cancer Prev. 2012;13 Suppl:83-7.
The prevalence of HBV and HCV infection among 295 cholangiocarcinoma (CCA) patients in northeast Thailand was analyzed. Hepatitis B surface antigen (HBsAg) was detected in 8.8% (26/295 cases) and antibodies to HCV (anti-HCV) in 2.7% (8/295 cases) of CCA cases. Screening for HBV DNA was performed in 15 of 26 HBV seropositive cases and genotypes could be determined in all 15. HBV genotypes C and B were detected in 73.3% (11/15 cases) and 26.7% (4/15 cases), respectively. HCV RNA was detected in 87.5% (7/8 cases) of anti-HCV positive cases. Specifically, 57.1% (4/7 cases) were HCV genotype 1a and 42.9% (3/7 cases) were HCV genotype 3a. The prevalence of infection and genotype distribution of both HCV and HBV among CCA in northeast Thailand is comparable to that in the general population, suggesting that HCV and HBV infections are, if at all, not serious risk factors for CCA.
对泰国东北部295例胆管癌（CCA）患者的HBV和HCV感染率进行了分析。在CCA病例中，8.8%（26/295例）检测到乙肝表面抗原（HBsAg），2.7%（8/295例）检测到抗HCV抗体。对26例HBV血清学阳性病例中的15例进行了HBV DNA筛查，所有15例均能确定基因型。分别在73.3%（11/15例）和26.7%（4/15例）中检测到HBV基因型C和B。在87.5%（7/8例）抗HCV阳性病例中检测到HCV RNA。具体而言，57.1%（4/7例）为HCV基因型1a，42.9%（3/7例）为HCV基因型3a。泰国东北部CCA患者中HCV和HBV的感染率及基因型分布与普通人群相当，这表明HCV和HBV感染即便存在，也并非CCA的严重危险因素。
