Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, and King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand.
Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
World J Gastroenterol. 2017 Oct 21;23(39):7160-7167. doi: 10.3748/wjg.v23.i39.7160.
To identify the potential risk factors of cholangiocarcinoma, we determined the characteristics of cholangiocarcinoma patients among 5 different regions of Thailand.
All patients diagnosed with cholangiocarcinoma between 2008 and 2013 were identified using the Nationwide Hospital Admission Data registry ( = 39421). Baseline characteristics, comorbidities and survival were abstracted.
The annual incidence during the study period was stable in all regions. Most patients lived in the Northeast (62.8%), followed by the North (16.9%), Central (12.3%), Bangkok (5.4%), and South ( = 2.6%) regions ( < 0.0001). Significantly more cholangiocarcinoma patients had diabetes, cirrhosis, and chronic viral hepatitis B/C infection than non-cholangiocarcinoma participants (diabetes: 11.42% 5.28%; cirrhosis: 4.81% 0.92%; hepatitis B: 0.74% 0.12%; and hepatitis C: 0.50% 0.10%, < 0.0001 for all, respectively). The overall 1-year mortality rate was 81.7%, with a stable trend over time.
Diabetes and chronic liver diseases may be associated with cholangiocarcinoma in the Thai population.
为了确定胆管癌的潜在风险因素，我们确定了泰国 5 个不同地区胆管癌患者的特征。
利用全国住院数据登记系统（n = 39421），确定了 2008 年至 2013 年间所有被诊断为胆管癌的患者。提取了基线特征、合并症和生存情况。
在研究期间，所有地区的年度发病率都保持稳定。大多数患者居住在东北部（62.8%），其次是北部（16.9%）、中部（12.3%）、曼谷（5.4%）和南部（2.6%）（<0.0001）。与非胆管癌患者相比，胆管癌患者中糖尿病、肝硬化和慢性乙型/丙型肝炎病毒感染的比例显著更高（糖尿病：11.42% 5.28%；肝硬化：4.81% 0.92%；乙型肝炎：0.74% 0.12%；丙型肝炎：0.50% 0.10%，均<0.0001）。总的 1 年死亡率为 81.7%，且呈稳定趋势。
在泰国人群中，糖尿病和慢性肝脏疾病可能与胆管癌有关。
