Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia.
Institute of Experimental Medicine, Faculty of Medicine, University of Pavol Jozef Šafárik, 040 11 Košice, Slovakia.
Int J Mol Sci. 2020 Oct 30;21(21):8133. doi: 10.3390/ijms21218133.
The human virome, which is a collection of all the viruses that are present in the human body, is increasingly being recognized as an essential part of the human microbiota. The human gastrointestinal tract and related organs (e.g., liver, pancreas, and gallbladder)-composing the gastrointestinal (or digestive) system-contain a huge number of viral particles which contribute to maintaining tissue homeostasis and keeping our body healthy. However, perturbations of the virome steady-state may, both directly and indirectly, ignite/sustain oncogenic mechanisms contributing to the initiation of a dysplastic process and/or cancer progression. In this review, we summarize and discuss the available evidence on the association and role of viruses in the development of cancers of the digestive system.
人类病毒组是指存在于人体中的所有病毒的集合,它越来越被认为是人类微生物组的重要组成部分。人类胃肠道及相关器官(如肝脏、胰腺和胆囊)——构成胃肠道(或消化系统)——包含大量的病毒颗粒,这些颗粒有助于维持组织内稳态并保持我们的身体健康。然而,病毒组稳态的波动可能会直接或间接地引发/维持致癌机制,从而促进发育异常过程和/或癌症进展。在这篇综述中,我们总结和讨论了现有关于病毒在消化系统癌症发展中的关联和作用的证据。