Oh Jin-Kyoung, Alemany Laia, Suh Jung-Il, Rha Seo-Hee, Muñoz Nubia, Bosch F Xavier, Quint Wim, Lloveras Belen, Klaustermeier Jo Ellen, de Sanjosé Silvia, Shin Hai-Rim
National Cancer Center, Korea.
Asian Pac J Cancer Prev. 2010;11(4):993-1000.
To describe the HPV genotype distribution and to investigate the underlying secular trend in the relative contribution of HPV types 16-18 in invasive cervical cancer (ICC) over a period of 47 years (1958-2004) in South Korea.
Paraffin embedded ICC samples were obtained from historical archives of two hospitals in Korea. HPV detection and genotyping was performed by SPF10 PCR, DEIA and LiPA25 assays (version 1).
Of 874 ICC cases, 742 were considered suitable for HPV DNA testing after histological evaluation. Squamous cell carcinoma was the major histological type (93.0%). HPV was detected in 674 of the 742 specimens (90.8%). The five most common types identified as single types among HPV-positive cases were HPV16 (63.1%), HPV18 (8.5%), HPV33 (4.5%), HPV58 (3.9%) and HPV31 (3.0%). Multiple infections were detected in 5%. HPV16-18 together accounted for 72% of all HPV-positive cervical cancers with no statistically significant differences by time at diagnosis (adjusted model-p>0.05).
This present study confirmed the role of HPV infection as the main factor in cervical cancer in Korea. HPV16-18 accounted for more than 70% in cervical cancer and there was no statistically significant secular trend for the past 50 years.
描述韩国47年（1958 - 2004年）间浸润性宫颈癌（ICC）中HPV基因型分布情况，并调查HPV 16 - 18型相对贡献的潜在长期趋势。
从韩国两家医院的历史档案中获取石蜡包埋的ICC样本。采用SPF10 PCR、DEIA和LiPA25检测法（第1版）进行HPV检测和基因分型。
在874例ICC病例中，经组织学评估后，742例被认为适合进行HPV DNA检测。鳞状细胞癌是主要的组织学类型（93.0%）。742份标本中有674份检测到HPV（90.8%）。在HPV阳性病例中，最常见的五种单一类型分别是HPV16（63.1%）、HPV18（8.5%）、HPV33（4.5%）、HPV58（3.9%）和HPV31（3.0%）。5%检测到多重感染。HPV 16 - 18型在所有HPV阳性宫颈癌中占72%，诊断时间上无统计学显著差异（校正模型 - p>0.05）。
本研究证实了HPV感染在韩国宫颈癌中作为主要因素的作用。HPV 16 - 18型在宫颈癌中占比超过70%，过去50年无统计学显著的长期趋势。
