Kim Min-Jeong, Kim Jin Ju, Kim Sunmie
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. ; Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea.
Obstet Gynecol Sci. 2013 Mar;56(2):110-20. doi: 10.5468/OGS.2013.56.2.110. Epub 2013 Mar 12.
We investigated the type-specific high-risk human papillomavirus (HPV) prevalence and distribution according to cervical cytology and age in healthy Korean women.
A retrospective cross-sectional study was conducted with 7,014 consecutive subjects undergoing both liquid-based cervical cytology and HPV genotyping test by DNA chip for cervical cancer screening. The type-specific prevalence and distribution of individual high-risk HPV types were assessed according to cervical cytology and age groups (<30, 30-39, 40-49, 50-59, and ≥60 years old).
In total, the most common HPV genotype was HPV58 (23.9% of all high-risk HPV-positive subjects), followed by HPV16 (21.8%), HPV52 (16.6%), and HPV18 (11.7%). Regarding cervical cytology and age groups, the proportion of HPV56 strongly increased with the increasing severity of cervical cytology (P for trend=0.041). An age-specific decline in the overall high-risk HPV prevalence was reaffirmed, and the proportion of HPV52 declined markedly with age (P for trend=0.014).
The type-specific prevalence of high-risk HPV types significantly varies according to cervical cytology and age. It may imply that these types have different to develop into precancerous lesions in normal cervix.
我们根据宫颈细胞学检查结果和年龄，调查了健康韩国女性中特定类型的高危人乳头瘤病毒（HPV）的流行情况和分布。
对7014名连续接受液基宫颈细胞学检查和用于宫颈癌筛查的DNA芯片HPV基因分型检测的受试者进行了一项回顾性横断面研究。根据宫颈细胞学检查结果和年龄组（<30岁、30-39岁、40-49岁、50-59岁和≥60岁）评估了个体高危HPV类型的特定类型流行情况和分布。
总体而言，最常见的HPV基因型是HPV58（在所有高危HPV阳性受试者中占23.9%），其次是HPV16（21.8%）、HPV52（16.6%）和HPV18（11.7%）。关于宫颈细胞学检查结果和年龄组，HPV56的比例随着宫颈细胞学严重程度的增加而显著增加（趋势P=0.041）。再次确认了总体高危HPV流行率随年龄的下降，并且HPV52的比例随年龄显著下降（趋势P=0.014）。
高危HPV类型的特定类型流行率根据宫颈细胞学检查结果和年龄有显著差异。这可能意味着这些类型在正常宫颈中发展为癌前病变的可能性不同。
