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右美托咪定：探索其在姑息治疗中用于顽固性疼痛的潜在作用及给药指南。

Dexmedetomidine: exploring its potential role and dosing guideline for its use in intractable pain in the palliative care setting.

作者信息

Coyne Patrick J, Wozencraft Colin P, Roberts Seth B, Bobb Barton, Smith Thomas J

机构信息

Thomas Palliative Care Program, Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia, USA.

出版信息

J Pain Palliat Care Pharmacother. 2010 Dec;24(4):384-6. doi: 10.3109/15360288.2010.518227.

DOI:10.3109/15360288.2010.518227
PMID:21133747
Abstract

Intractable pain continues to pose problems for patients with life-limiting disease. The authors review the potential role of dexmedetomidine (Precedex), an α(2)-adrenergic agonist, as a bridge to obtaining effective analgesia. The authors offer criteria to consider in utilizing this medication within the context of palliative care.

摘要

顽固性疼痛仍然给患有危及生命疾病的患者带来问题。作者回顾了α₂肾上腺素能激动剂右美托咪定（Precedex）作为获得有效镇痛桥梁的潜在作用。作者提供了在姑息治疗背景下使用这种药物时应考虑的标准。

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Dexmedetomidine: exploring its potential role and dosing guideline for its use in intractable pain in the palliative care setting.右美托咪定：探索其在姑息治疗中用于顽固性疼痛的潜在作用及给药指南。
J Pain Palliat Care Pharmacother. 2010 Dec;24(4):384-6. doi: 10.3109/15360288.2010.518227.
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Review article: dexmedetomidine: does it have potential in palliative medicine?综述文章：右美托咪定：它在姑息医学中有潜力吗？
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Dexmedetomidine: a novel analgesic with palliative medicine potential.右美托咪定：一种具有姑息医学潜力的新型镇痛药。
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[Three successful cases of continuous dexmedetomidine infusion for the treatment of intractable delirium associated with cancer pain].[持续输注右美托咪定治疗癌痛相关性顽固性谵妄3例成功病例]
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New therapeutic uses for an alpha2 adrenergic receptor agonist--dexmedetomidine in pain management.一种用于疼痛管理的 α2 肾上腺素能受体激动剂——右美托咪定的新治疗用途。
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Controlling cancer pain with pharmacotherapy.药物治疗控制癌痛
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[The effect of perioperative infused dexmedetomidine on postoperative analgesic consumption in mastoidectomy operations].[围手术期输注右美托咪定对乳突切除术术后镇痛药物用量的影响]
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Intraoperative infusion of dexmedetomidine reduces perioperative analgesic requirements.术中输注右美托咪定可降低围手术期镇痛需求。
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引用本文的文献

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Applications of Dexmedetomidine in Palliative and Hospice Care.右美托咪定在姑息治疗和临终关怀中的应用。
J Pediatr Pharmacol Ther. 2022;27(7):587-594. doi: 10.5863/1551-6776-27.7.587. Epub 2022 Sep 26.
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Intravenous Dexmedetomidine Administration Prior Anesthesia Induction With Propofol at 4°C Attenuates Propofol Injection Pain: A Double-Blind, Randomized, Placebo-Controlled Trial.在4°C下于丙泊酚麻醉诱导前静脉注射右美托咪定可减轻丙泊酚注射痛：一项双盲、随机、安慰剂对照试验。
Front Med (Lausanne). 2021 May 7;8:590465. doi: 10.3389/fmed.2021.590465. eCollection 2021.
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Reflections on palliative sedation.
关于姑息性镇静的思考
Palliat Care. 2019 Jan 27;12:1178224218823511. doi: 10.1177/1178224218823511. eCollection 2019.
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A new approach to the prevention and treatment of delirium in elderly patients in the intensive care unit.一种针对重症监护病房老年患者谵妄预防和治疗的新方法。
J Community Hosp Intern Med Perspect. 2015 Sep 1;5(4):27950. doi: 10.3402/jchimp.v5.27950. eCollection 2015.