Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada.
Dermatol Surg. 2010 Dec;36 Suppl 4:2168-71. doi: 10.1111/j.1524-4725.2010.01708.x.
OnabotulinumtoxinA is an established treatment for glabellar frown lines, but its effects on lines at repose are less well documented.
To assess the effect of onabotulinumtoxinA on elimination of mild lines at repose.
Data from two randomized, double-blind, placebo-controlled studies were included. Elimination of mild lines at repose was defined as change from mild to none on the Facial Wrinkle Scale.
Analysis included 183 participants who received 20 U of onabotulinumtoxinA and 64 participants who received placebo, all with mild lines at repose at baseline. Participants were evaluated 7, 30, 60, 90, and 120 days posttreatment. Compared to placebo, onabotulinumtoxinA-treated participants were significantly more likely to have their lines at repose eliminated at each study day; [odds ratios ranged from 42.7 (95% confidence interval (CI)=12.9-141.9) at day 30 to 4.9 (95% CI=2.2-10.8) at day 120 (p<.0001 at each day)]. The highest response rate was observed at day 30 (68%).
OnabotulinumtoxinA has demonstrated the ability to eliminate mild glabellar lines at repose for a significant number of patients. This effect, albeit more subtle than the effect on dynamic or more severe glabellar lines, may be an important treatment goal for patients who seek a smoother appearance at repose.
肉毒毒素 A 是治疗眉间竖纹的成熟疗法，但关于其对休息时皱纹的效果的文献记载较少。
评估肉毒毒素 A 对消除轻度休息时皱纹的效果。
纳入了两项随机、双盲、安慰剂对照研究的数据。消除轻度休息时皱纹的定义为在面部皱纹量表上从轻度变为无。
分析纳入了 183 名接受 20U 肉毒毒素 A 治疗和 64 名接受安慰剂治疗的参与者，所有参与者基线时均有轻度休息时皱纹。参与者在治疗后 7、30、60、90 和 120 天接受评估。与安慰剂相比，接受肉毒毒素 A 治疗的参与者在每个研究日更有可能消除休息时的皱纹；[优势比范围从第 30 天的 42.7（95%置信区间（CI）=12.9-141.9）到第 120 天的 4.9（95%CI=2.2-10.8）（p<.0001，在每个日期间）]。在第 30 天观察到最高的应答率（68%）。
肉毒毒素 A 已证明有能力消除相当多患者的轻度眉间休息时皱纹。这种效果虽然不如对动态或更严重的眉间皱纹的效果明显，但可能是寻求休息时更平滑外观的患者的一个重要治疗目标。
