Awad Hamdy, Abd El Dayem Mohamed, Heard Jarrett, Dimitrova Galina, Yu Lianbo, Sun Benjamin C
The Ohio State University Medical Center, Department of Anesthesiology, Columbus, 43210, USA.
J Cardiothorac Surg. 2010 Dec 6;5:123. doi: 10.1186/1749-8090-5-123.
We hypothesize that implantation of left ventricular assist device through off-pump technique is feasible and has a comparable result to implantation on cardiopulmonary bypass and could improve one-year survival.
This retrospective, observational, single-center study was conducted on 29 consecutive patients at our institution who underwent off-pump left ventricular assist device implantation by a single surgeon.
Twenty-seven procedures were performed successfully using the off-pump technique. The survival rate was 92% at 30 days, 76% at 90 days, and 67% at one year. We compared the one-year survival of different implantation periods, and divided our study into three time intervals (2004-2005, 2006, and 2007). There was a trend in reduction in number of deaths over one year that demonstrated a decrease in death rate from 50% to 17%, as well as improvement in our experience over time. However, this trend is not statistically significant (p = 0.08) due to limited sample size.
Based upon our findings, off-pump left ventricular assist device implantation is a feasible surgical technique, and combining this technique with improved device technology in the future may provide even greater improvement in patient outcomes.
我们假设通过非体外循环技术植入左心室辅助装置是可行的，其结果与在体外循环下植入相当，并且可以提高一年生存率。
本回顾性、观察性、单中心研究对我们机构连续29例由单一外科医生进行非体外循环左心室辅助装置植入的患者进行。
27例手术成功采用非体外循环技术完成。30天时生存率为92%，90天时为76%，一年时为67%。我们比较了不同植入时期的一年生存率，并将研究分为三个时间间隔（2004 - 2005年、2006年和2007年）。一年中死亡人数有减少趋势，死亡率从50%降至17%，且随着时间推移我们的经验有所改善。然而，由于样本量有限，这一趋势无统计学意义（p = 0.08）。
基于我们的研究结果，非体外循环左心室辅助装置植入是一种可行的外科技术，未来将该技术与改进的装置技术相结合可能会使患者预后得到更大改善。
