Beckman Institute for Advanced Science and Technology, Urbana, IL 61801, USA.
IEEE Trans Biomed Eng. 2011 Mar;58(3):741-4. doi: 10.1109/TBME.2010.2096816. Epub 2010 Dec 3.
The goal of this study is to develop an advanced point-of-care diagnostic instrument for use in a primary care office using handheld optical coherence tomography (OCT). This system has the potential to enable earlier detection of diseases and accurate image-based diagnostics. Our system was designed to be compact, portable, user-friendly, and fast, making it well suited for the primary care office setting. The unique feature of our system is a versatile handheld OCT imaging scanner which consists of a pair of computer-controlled galvanometer-mounted mirrors, interchangeable lens mounts, and miniaturized video camera. This handheld scanner has the capability to guide the physician in real time for finding suspicious regions to be imaged by OCT. In order to evaluate the performance and use of the handheld OCT scanner, the anterior chamber of a rat eye and in vivo human retina, cornea, skin, and tympanic membrane were imaged. Based on this feasibility study, we believe that this new type of handheld OCT device and system has the potential to be an efficient point-of-care imaging tool in primary care medicine.
本研究旨在开发一种基于手持光学相干断层扫描（OCT）的先进即时诊断仪器，用于初级保健诊室。该系统具有早期发现疾病和进行准确基于图像的诊断的潜力。我们的系统设计紧凑、便携、用户友好且快速，非常适合初级保健诊室环境。我们系统的独特之处在于一种多功能的手持式 OCT 成像扫描仪，它由一对计算机控制的振镜、可互换的镜头座和微型摄像机组成。这种手持式扫描仪能够实时引导医生找到要进行 OCT 成像的可疑区域。为了评估手持式 OCT 扫描仪的性能和用途，对大鼠眼前房和体内人视网膜、角膜、皮肤和鼓膜进行了成像。基于这项可行性研究，我们相信这种新型手持式 OCT 设备和系统有可能成为初级保健医学中一种高效的即时成像工具。
