Department of Endocrinology and Metabolism, The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping, Shenyang, China.
Endocr J. 2011;58(1):23-30. doi: 10.1507/endocrj.k10e-272. Epub 2010 Nov 30.
To explore the relationship between serum thyrotropin and components of metabolic syndrome in a Chinese cohort. A total of 1534 adult inhabitants in DaDong district of Shenyang were asked to fulfill the questionnaire, complete physical examination and OGTT. Blood samples were collected to test thyrotropin (TSH), fasting plasma glucose (FPG), OGTT 2h PG, fasting insulin (FINS), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C). Serum TSH in metabolic syndrome group was higher than that in the non-metabolic syndrome group (2.54 mIU/L vs. 2.22 mIU/L, p<0.05). TG level increased significantly in subclinical hypothyroid group compared with euthyroid subjects (1.73±0.12 mmol/L vs. 1.47±0.03 mmol/L, p<0.05), and HDL-C decreased significantly in patients with subclinical hypothyroidism compared with euthyroid subjects (1.26±0.27 mmol/L vs. 1.33±0.27 mmol/L, p<0.05). The prevalence of hypertension was higher in the subclinical hypothyroid group than that in euthyroid group (42.86% vs. 33.2%, p<0.05). The serum TSH within the reference range was positively related with the prevalence of overweight/obesity. Slight increase in serum TSH maybe a risk factor for metabolic syndrome.
探讨中国人群血清促甲状腺激素与代谢综合征组分的关系。 共招募沈阳市大东区 1534 名成年居民，要求其填写问卷、完成体格检查和 OGTT。采集血样以检测促甲状腺激素（TSH）、空腹血糖（FPG）、OGTT 2hPG、空腹胰岛素（FINS）、甘油三酯（TG）和高密度脂蛋白胆固醇（HDL-C）。代谢综合征组血清 TSH 高于非代谢综合征组（2.54mIU/L 比 2.22mIU/L，p<0.05）。亚临床甲状腺功能减退组的 TG 水平明显高于甲状腺功能正常组（1.73±0.12mmol/L 比 1.47±0.03mmol/L，p<0.05），亚临床甲状腺功能减退组的 HDL-C 水平明显低于甲状腺功能正常组（1.26±0.27mmol/L 比 1.33±0.27mmol/L，p<0.05）。亚临床甲状腺功能减退组高血压患病率高于甲状腺功能正常组（42.86%比 33.2%，p<0.05）。参考范围内的血清 TSH 与超重/肥胖的患病率呈正相关。血清 TSH 轻度升高可能是代谢综合征的危险因素。
