Department of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, University of Duisburg-Essen, Essen, Germany.
Dement Geriatr Cogn Disord. 2011;31(1):37-44. doi: 10.1159/000322370. Epub 2010 Dec 7.
BACKGROUND/AIMS: We determined cerebrospinal fluid (CSF) concentrations of amyloid-β (Aβ)(1-38), Aβ(1-40), Aβ(1-42), total tau and phospho-tau (p-tau) in order to study their differential expression in frontotemporal dementia (FTD, n = 25) and primary progressive aphasia (PPA, n = 12) as compared to Alzheimer's dementia (AD, n = 25) and nondemented controls (n = 20).
Commercially available ELISA and electrochemiluminescence methods were applied.
High CSF p-tau and low ratios of Aβ(1-42)/Aβ(1-40) and Aβ(1-42)/Aβ(1-38), respectively, were specific for AD. CSF Aβ(1-38) was reduced in FTD as compared to each of the other diagnostic groups, including PPA. CSF tau and p-tau levels were elevated in PPA as compared to FTD.
This is the first detailed report on biomarker patterns in PPA, indicating distinct CSF biomarker patterns in FTD and PPA as major subgroups of frontotemporal lobar degeneration. The diagnostic and pathophysiological implications of our results warrant further studies on larger and neuropathologically diagnosed patient populations.
背景/目的：我们测定了脑脊液（CSF）中淀粉样蛋白-β（Aβ）（1-38）、Aβ（1-40）、Aβ（1-42）、总 tau 和磷酸化 tau（p-tau）的浓度，以便研究它们在额颞叶痴呆（FTD，n=25）和原发性进行性失语症（PPA，n=12）中的差异表达，与阿尔茨海默病（AD，n=25）和非痴呆对照（n=20）相比。
应用了商业上可用的 ELISA 和电化学发光方法。
高 CSF p-tau 和低 Aβ（1-42）/Aβ（1-40）和 Aβ（1-42）/Aβ（1-38）的比值分别是 AD 的特异性标志物。与其他诊断组相比，包括 PPA，FTD 的 CSF Aβ（1-38）水平降低。与 FTD 相比，PPA 的 CSF tau 和 p-tau 水平升高。
这是 PPA 中生物标志物模式的第一个详细报告，表明 FTD 和 PPA 作为额颞叶变性的主要亚组具有不同的 CSF 生物标志物模式。我们研究结果的诊断和病理生理学意义需要进一步研究更大的、经神经病理学诊断的患者群体。
