Department of Medicine/Cardiology, Cardiovascular Research Laboratories, University of California, Los Angeles, CA, USA; Department of Physiology, Cardiovascular Research Laboratories, University of California, Los Angeles, CA, USA.
Proteomics Clin Appl. 2008 Jun;2(6):837-44. doi: 10.1002/prca.200780121.
Cardiovascular disease is the leading cause of death and disability in the developed world. To design novel therapeutic strategies to treat and prevent this disease, better understanding of cardiac cell function is necessary. In addition to (and, indeed, in combination with) genetics, physiology and molecular biology, proteomics plays a critical role in our understanding of cardiovascular systems at multiple scales. The purpose of this review is to examine recent developments in the field of myocardial injury and protection, examining how proteomics has informed investigations into organelles, signaling complexes, and cardiac phenotype.
心血管疾病是发达国家死亡和残疾的主要原因。为了设计治疗和预防这种疾病的新的治疗策略，有必要更好地了解心脏细胞的功能。除了（实际上，与）遗传学、生理学和分子生物学之外，蛋白质组学在我们从多个尺度理解心血管系统方面发挥着关键作用。本文的目的是检查心肌损伤和保护领域的最新进展，研究蛋白质组学如何为细胞器、信号复合物和心脏表型的研究提供信息。
