颅内血管外皮细胞瘤和血管母细胞瘤的组织发生。一项免疫组织化学研究。

Histogenesis of intracranial haemangiopericytoma and haemangioblastoma. An immunohistochemical study.

作者信息

Theunissen P H, Debets-Te Baerts M, Blaauw G

机构信息

Department of Pathology, De Wever Hospital, Heerlen, The Netherlands.

出版信息

Acta Neuropathol. 1990;80(1):68-71. doi: 10.1007/BF00294223.

DOI:10.1007/BF00294223

PMID:2113758

Abstract

An immunohistochemical study was performed on three meningeal haemangiopericytomas and four cerebellar haemangioblastomas (paraffin embedded) in an attempt to elucidate the uncertain histogenesis of these tumours. The tumour cells of all meningeal haemangiopericytomas show no expression of alpha-smooth muscle actin and, thus, no immunohistochemical proof of their true pericytic nature can be obtained. The stromal cells of cerebellar haemangioblastomas show foci of positive staining for S-100 protein, neuron-specific enolase and synaptophysin, thereby clearly indicating their neuroectodermal origin. These results allow the conclusion that the present nomenclature of these tumours is at least arguable and probably incorrect.

摘要

对3例脑膜血管外皮细胞瘤和4例小脑成血管细胞瘤（石蜡包埋）进行了免疫组织化学研究，以阐明这些肿瘤不确定的组织发生。所有脑膜血管外皮细胞瘤的肿瘤细胞均未显示α-平滑肌肌动蛋白表达，因此，无法获得其真正周细胞性质的免疫组织化学证据。小脑成血管细胞瘤的基质细胞显示S-100蛋白、神经元特异性烯醇化酶和突触素呈阳性染色灶，从而明确表明其神经外胚层起源。这些结果表明，这些肿瘤目前的命名至少是有争议的，可能是不正确的。