Université Pierre et Marie Curie-Paris, UMR S, France.
AIDS. 2011 Feb 20;25(4):537-9. doi: 10.1097/QAD.0b013e32834345d3.
The aim of this study was to analyse tropism evolution in HIV-1 patients with at least 2 years of viral load undetectability. For this purpose, HIV-1-infected antiretroviral-treated patients (n = 128) with a viral load less than 50 copies/ml for 4 years in median were studied. No change of virus tropism was observed in 92.9% of patients. Therefore, before the use of CCR5 antagonists, genotypic viral DNA tropism determination is an available tool.
本研究旨在分析至少 2 年病毒载量不可检测的 HIV-1 患者的病毒嗜性演变。为此，对中位时间为 4 年病毒载量＜50 拷贝/ml 的 128 例接受抗逆转录病毒治疗的 HIV-1 感染患者进行了研究。92.9%的患者未观察到病毒嗜性变化。因此，在使用 CCR5 拮抗剂之前，基因型病毒 DNA 嗜性测定是一种可用的工具。
