Glycotechnology Business Unit, Japan Tobacco Inc., 700 Higashibara, Iwata, Shizuoka 438-0802, Japan.
Mar Drugs. 2010 Nov 5;8(11):2781-94. doi: 10.3390/md8112781.
Sialyltransferases transfer N-acetylneuraminic acid (Neu5Ac) from the common donor substrate of these enzymes, cytidine 5'-monophospho-N-acetylneuraminic acid (CMP-Neu5Ac), to acceptor substrates. The enzymatic reaction products including sialyl-glycoproteins, sialyl-glycolipids and sialyl-oligosaccharides are important molecules in various biological and physiological processes, such as cell-cell recognition, cancer metastasis, and virus infection. Thus, sialyltransferases are thought to be important enzymes in the field of glycobiology. To date, many sialyltransferases and the genes encoding them have been obtained from various sources including mammalian, bacterial and viral sources. During the course of our research, we have detected over 20 bacteria that produce sialyltransferases. Many of the bacteria we isolated from marine environments are classified in the genus Photobacterium or the closely related genus Vibrio. The paper reviews the sialyltransferases obtained mainly from marine bacteria.
唾液酸转移酶将 N-乙酰神经氨酸（Neu5Ac）从这些酶的共同供体底物胞苷 5'-单磷酸 N-乙酰神经氨酸（CMP-Neu5Ac）转移到受体底物上。酶促反应产物包括唾液酸化糖蛋白、唾液酸化糖脂和唾液酸化寡糖，是各种生物和生理过程中的重要分子，如细胞-细胞识别、癌症转移和病毒感染。因此，唾液酸转移酶被认为是糖生物学领域的重要酶。迄今为止，已经从哺乳动物、细菌和病毒等各种来源获得了许多唾液酸转移酶及其编码基因。在我们的研究过程中，我们已经检测到超过 20 种产生唾液酸转移酶的细菌。我们从海洋环境中分离出的许多细菌属于发光杆菌属或密切相关的弧菌属。本文综述了主要从海洋细菌中获得的唾液酸转移酶。
