Kotze Lorete Maria da Silva, Nisihara Renato Mitsunori, Utiyama Shirley Ramos da Rosa, Kotze Paulo Gustavo, Theiss Petra Mirella, Olandoski Márcia
Hospital Cajuru, Pontifícia Universidade Católica do Paraná, Brazil.
Arq Gastroenterol. 2010 Jul-Sep;47(3):242-5. doi: 10.1590/s0004-28032010000300006.
Anti-Saccharomyces cerevisiae antibodies (ASCA), considered serologic markers for Crohn's disease, were described in patients with celiac disease, disappearing after a gluten-free diet.
Evaluation of ASCA positivity in patients with Crohn's disease and celiac disease in relation to healthy individuals.
A total of 145 individuals were studied: 36 with Crohn's disease and 52 with celiac disease, that fulfilled the diagnostic criteria for both affections, and 57 healthy individuals for control. The celiac patients were divided as follow: group CeD I at diagnosis (n = 34), group CeD II with gluten-free diet compliance (n = 13) and group CeD III with transgressions to the diet (n = 5). ASCA IgA and IgG were determined by ELISA.
With statistical significance, ASCA IgA were positive in Crohn's disease, celiac disease at diagnosis and celiac disease with diet transgressions; ASCA IgG in Crohn's disease and in all groups with celiac disease.
The detection of ASCA in patients with celiac disease allows to suggest that ASCA is not a specific marker for Crohn's disease, but was associated with the inflammation of the small intestine. The increased levels of positive ASCA may be due to genetic factors and increased intestinal permeability.
抗酿酒酵母抗体（ASCA）被认为是克罗恩病的血清学标志物，在乳糜泻患者中也有发现，在无麸质饮食后会消失。
评估克罗恩病和乳糜泻患者与健康个体相比的ASCA阳性情况。
共研究了145名个体：36名克罗恩病患者和52名乳糜泻患者，这两组患者均符合两种疾病的诊断标准，还有57名健康个体作为对照。乳糜泻患者分为以下几组：诊断时的CeD I组（n = 34）、遵循无麸质饮食的CeD II组（n = 13）和违反饮食规定的CeD III组（n = 5）。通过酶联免疫吸附测定法测定ASCA IgA和IgG。
具有统计学意义的是，ASCA IgA在克罗恩病、诊断时的乳糜泻以及违反饮食规定的乳糜泻患者中呈阳性；ASCA IgG在克罗恩病以及所有乳糜泻组中呈阳性。
在乳糜泻患者中检测到ASCA表明，ASCA不是克罗恩病的特异性标志物，而是与小肠炎症相关。ASCA阳性水平升高可能归因于遗传因素和肠道通透性增加。
