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抗 Hwp1 抗体和抗 ASCA 抗体的同时出现，这两种抗体分别针对不同的分子靶标，进一步证实了这种真菌物种与乳糜泻之间的关联。

Coincidence of antibodies against Hwp1 and ASCA, two distinct molecular targets of , reinforces the link between this fungal species and coeliac disease.

机构信息

CNRS, UMR 8576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, Univ INSERM U1285, Lille, France.

CHU Lille, Laboratoire de Parasitologie-Mycologie, Lille, France.

出版信息

Virulence. 2024 Dec;15(1):2334085. doi: 10.1080/21505594.2024.2334085. Epub 2024 Mar 26.

DOI:10.1080/21505594.2024.2334085
PMID:38528835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10968292/
Abstract

is an immunogen for anti- antibodies (ASCA), a serological marker of Crohn's disease. ASCA has also been reported in other autoimmune diseases, including coeliac disease (CeD). A strong antibody response against Hwp1, a protein associated with invasive hyphal form of which presents peptide sequence homologies with gliadin, has also been described in CeD. This observation supports the hypothesis that hyphal transition in may trigger CeD onset through a mechanism of molecular/antigenic mimicry. In this study, we assessed whether the anti- oligomannose and anti-Hwp1 protein responses may be linked despite their different pathophysiological significance. The measurement of ASCA levels in a cohort of patients involved in our previous Hwp1 study showed a significant correlation between the two biomarkers. This new observation further reinforces the link between and CeD.

摘要

是抗抗体（ASCA）的免疫原，ASCA 也是克罗恩病的血清学标志物。ASCA 也在其他自身免疫性疾病中被报道过，包括乳糜泻（CeD）。在 CeD 中也描述了针对与侵袭性菌丝形式相关的 Hwp1 蛋白的强烈抗体反应，该蛋白与麦胶蛋白具有肽序列同源性。这一观察结果支持了这样一种假说，即在 中菌丝的转变可能通过分子/抗原模拟的机制引发 CeD 的发病。在这项研究中，我们评估了抗寡甘露糖和抗 Hwp1 蛋白反应是否可能存在关联，尽管它们具有不同的病理生理意义。在我们之前的 Hwp1 研究中，对一组患者的 ASCA 水平进行测量，结果显示这两种生物标志物之间存在显著相关性。这一新的观察结果进一步加强了 与 CeD 之间的联系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e50d/10968292/aa67f1dbf319/KVIR_A_2334085_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e50d/10968292/01c1630dd2c5/KVIR_A_2334085_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e50d/10968292/aa67f1dbf319/KVIR_A_2334085_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e50d/10968292/01c1630dd2c5/KVIR_A_2334085_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e50d/10968292/aa67f1dbf319/KVIR_A_2334085_F0002_OC.jpg

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Human glycoprotein-2 expressed in Brunner glands - A putative autoimmune target and link between Crohn's and coeliac disease.人 Brunners 腺糖蛋白-2 - 一种潜在的自身免疫性靶标及克罗恩病和乳糜泻之间的联系。
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Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity.
黏膜真菌通过 17 型免疫促进肠道屏障功能和社交行为。
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Candida albicans in celiac disease: A wolf in sheep's clothing.麸质肠病中的白色念珠菌：披着羊皮的狼。
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