Shakya K, Shrestha J K, Joshi S N
Mechi Eye Care Center Birtamod, Jhapa Nepal.
Nepal J Ophthalmol. 2009 Jul-Dec;1(2):107-13. doi: 10.3126/nepjoph.v1i2.3684.
diabetic retinopathy is the leading cause of blindness of working-age patients in the urban areas.
to find out the association between diabetic retinopathy and serum lipoproteins in patients with diabetes mellitus
a community-based cross-sectional study involving 100 subjects with type II diabetes living in the cities of Kathmandu, Bhaktapur and Lalitpur of Nepal was carried out using a purposive sampling method. The retinopathy was classified according to the modified Airlie House classification of diabetic retinopathy. The patients with systolic hypertension were excluded. The blood sugar level was assessed by using glycosylated hemoglobin. The fasting serum lipoproteins were assessed by photometric enzymatic methods.
the SPSS version 10.0 software was used. The p value of <0.05 was considered significant.
the majority (n=91) of the patients were in the age group 31-60 years with the mean of 48.2 +/- 9.5. The mean duration of diabetes mellitus in the patients with no-diabetic-retinopathy was 4 +/- 3.4 years and that in those with the retinopathy was 6.4 +/- 4years, (p =0.006). The mean glycosylated hemoglobin level for no-diabetic-retinopathy group was 6.9 1.1%, whereas for the diabetic retinopathy group, it was 7.7 +/- 1.5% (p = 0.004). The mean values of serum lipoproteins when taken together were slightly higher in the diabetic retinopathy group than in the group with no-diabetic-retinopathy. The serum triglyceride value was higher in the group with diabetic retinopathy than in the group with no retinopathy. Serum triglyceride had a low degree of positive correlation with HbA lc value.
there is no significant association between the serum lipoprotein levels and diabetic retinopathy in patients with type II diabetes mellitus. Serum triglyceride level has a low degree of positive correlation with HbA lc value.
糖尿病视网膜病变是城市地区劳动年龄患者失明的主要原因。
探讨糖尿病患者糖尿病视网膜病变与血清脂蛋白之间的关联。
采用立意抽样法，在尼泊尔加德满都、巴克塔普尔和勒利德布尔市开展了一项基于社区的横断面研究，纳入100例Ⅱ型糖尿病患者。根据改良的阿利屋糖尿病视网膜病变分类法对视网膜病变进行分类。排除收缩期高血压患者。采用糖化血红蛋白评估血糖水平。采用光度酶法评估空腹血清脂蛋白。
使用SPSS 10.0软件。p值<0.05被认为具有统计学意义。
大多数患者（n = 91）年龄在31 - 60岁之间，平均年龄为48.2±9.5岁。无糖尿病视网膜病变患者的糖尿病平均病程为4±3.4年，有视网膜病变患者的糖尿病平均病程为6.4±4年，（p = 0.006）。无糖尿病视网膜病变组的平均糖化血红蛋白水平为6.9±1.1%，而糖尿病视网膜病变组为7.7±1.5%（p = 0.004）。糖尿病视网膜病变组血清脂蛋白的平均值总体略高于无糖尿病视网膜病变组。糖尿病视网膜病变组的血清甘油三酯值高于无视网膜病变组。血清甘油三酯与糖化血红蛋白值呈低度正相关。
Ⅱ型糖尿病患者血清脂蛋白水平与糖尿病视网膜病变之间无显著关联。血清甘油三酯水平与糖化血红蛋白值呈低度正相关。
