Ren Junguo, Ma Xiaobin, Lin Chengren, Li Honghai, Wang Min, Li Junmei, Wang Yanghui, Liu Jianxun
Center for Experimental Research, Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing 100091, China.
Zhongguo Zhong Yao Za Zhi. 2010 Sep;35(18):2469-74.
To provide a new approach for studying the compatibility principle of traditional Chinese medicine formula (TCMF) by constructing compatibility network of phamarcologic action of TCMF according to the network theory.
With Chinese herb as node and compatibility relationship of herb-herb as edge according to network theory, compatibility network of phamarcologic action of TCMF was constructed after the compatibility relationship of herb-herb was analysed by two-way analysis of variance (ANOVA)through phamarcology experiment. Then compatibility principle of TCMF was analysed with network efficiency (NE) and NE related parameters.
The network approach was applied for studying compatibility principle of Jiawei Shengmai San on it's antimyocardial ischemia reperfusion injury action. The results indicated that rhizoma corydalis was the main herb in Jiawei Shengmai San, and in turn was radix ophiopogonois, radix salvia miltiorrhiza, radix ginseng and fructus schizandrae, radix ginseng and radix salvia was clustered first, and in turn was radix, Formule composed of ophiopogonois and fructus schizandrae. Formule composed of radix ginseng and radix salvia, and radix ophiopogonois and fructus schizandrae; radix ginseng, radix salvia miltiorrhiza and rhizoma corydalis was the most effective one among all the formulaes. These results were consistent with validation experiments.
Studying compatibility principle of TCMF by network theory is a new and feasible method.
根据网络理论构建中药复方药理作用配伍网络，为研究中药复方配伍规律提供新方法。
以中药为节点，以药-药配伍关系为边，依据网络理论，通过药理实验采用双向方差分析（ANOVA）分析药-药配伍关系后，构建中药复方药理作用配伍网络。然后运用网络效率（NE）及NE相关参数分析中药复方配伍规律。
将网络方法应用于研究加味生脉散抗心肌缺血再灌注损伤作用的配伍规律。结果表明，延胡索是加味生脉散中的主要药物，其次是麦冬、丹参、人参和五味子，人参和丹参首先聚类，其次是麦冬和五味子组成的方剂。由人参和丹参、麦冬和五味子组成的方剂；人参、丹参和延胡索组成的方剂在所有方剂中最为有效。这些结果与验证实验一致。
利用网络理论研究中药复方配伍规律是一种新的可行方法。
