Barnes Jewish Hospital, St. Louis, Missouri, USA.
Oncology (Williston Park). 2010 Nov 15;24(12):1167-70.
Influenza infection is a potential cause of additional morbidity and mortality in patients who are immunocompromised because of cancer or its treatment. Of particular note, influenza infection may delay or interrupt chemotherapy and necessitate hospitalization. Successful immunization depends on an intact immune system that can produce antibodies in response to antigen exposure. Patients with cancer often have a suppressed immune system, resulting from their disease and/or immunosuppressive therapies, and as a consequence they may have a suboptimal serologic response to influenza vaccination. Since vaccination is the only proven method for preventing influenza infection, the Advisory Committee on Immunization Practices recommends seasonal influenza vaccination for adults without contraindications who have disease- or medication-related immunosuppression. Patients with cancer should be given the trivalent inactivated vaccine. Preliminary data suggest that administering the vaccine between cycles of chemotherapy may yield the best results.
流感感染是导致癌症或其治疗导致免疫功能低下的患者发生额外发病率和死亡率的潜在原因。值得特别注意的是，流感感染可能会延迟或中断化疗并需要住院治疗。成功的免疫接种取决于能够针对抗原暴露产生抗体的完整免疫系统。癌症患者通常由于疾病和/或免疫抑制治疗而免疫系统受到抑制，因此他们对流感疫苗接种的血清学反应可能不理想。由于疫苗接种是预防流感感染的唯一有效方法，免疫实践咨询委员会建议无禁忌症且患有疾病或药物相关免疫抑制的成年人进行季节性流感疫苗接种。癌症患者应接种三价灭活疫苗。初步数据表明，在化疗周期之间接种疫苗可能会产生最佳效果。
