大麻依赖青少年的线索反应性。
Cue reactivity in cannabis-dependent adolescents.
机构信息
Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478-9106, USA.
出版信息
Psychol Addict Behav. 2011 Mar;25(1):168-73. doi: 10.1037/a0021117.
Abstract
The authors measured event-related potentials with a craving manipulation to investigate the neural correlates of drug cue reactivity in 13 adolescents who are cannabis dependent (CD; ages 14-17). The P300 responses to marijuana (MJ) pictures (MJ-P300) and control pictures (C-P300) were assessed after handling neutral objects and again after handling MJ paraphernalia (MJP). Self-reported drug craving and heart rates also were measured. MJ-P300 were larger than C-P300 (p < .001), and both the MJ-P300 and craving increased significantly after handling MJP (p = .002 and p = .003, respectively), with no association between the magnitude of craving and MJ-P300. Heart rates were not affected by handling MJP. The results showed that adolescents who are CD have an attentional bias to MJ stimuli that increases after handling marijuana paraphernalia. Generally, the results are consistent with what has been reported for adult heavy chronic cannabis smokers, although there were some differences that require further investigation.
摘要
作者通过使用一种渴望操作来测量事件相关电位，以研究 13 名大麻依赖青少年（年龄 14-17 岁）对药物线索反应的神经相关性。在处理中性物体后和再次处理大麻用具（MJP）后，评估了大麻（MJ）图片（MJ-P300）和对照图片（C-P300）的 P300 反应。还测量了自我报告的药物渴望和心率。MJ-P300 大于 C-P300（p <.001），并且在处理 MJP 后，MJ-P300 和渴望均显着增加（p =.002 和 p =.003），渴望的程度与 MJ-P300 之间没有关联。处理 MJP 不会影响心率。结果表明，大麻依赖的青少年对 MJ 刺激存在注意力偏向，这种偏向在处理大麻用具后会增加。总的来说，这些结果与成人重度慢性大麻吸烟者的报告一致，尽管存在一些需要进一步研究的差异。
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Clin Neurophysiol. 2009 Nov;120(11):1883-1908. doi: 10.1016/j.clinph.2009.07.045. Epub 2009 Sep 30.
2
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3
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