干扰素诱导基因：Viperin。
The interferon inducible gene: Viperin.
机构信息
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
出版信息
J Interferon Cytokine Res. 2011 Jan;31(1):131-5. doi: 10.1089/jir.2010.0127. Epub 2010 Dec 12.
Abstract
The type I interferons (IFNs), IFN-α and -β, are key effector molecules of the immune response to viruses. The anti-viral action of IFNs on virus-infected cells and surrounding tissues is mediated by expression of hundreds of IFN-stimulated genes. Viperin (virus inhibitory protein, endoplasmic reticulum-associated, IFN-inducible) is an Interferon stimulated gene (ISG), which is induced by type I, II, and III IFNs or after infection with a broad range of DNA and RNA viruses. Recent evidence indicates that Viperin disrupts lipid rafts to block influenza virus budding and release and interferes with replication of hepatitis C virus by binding to lipid droplets, small organelles involved in lipid homeostasis that are essential for hepatitis C virus replication. Viperin is also induced by nonviral microbial products such as lipopolysaccharide (LPS) and by a wide range of bacteria, suggesting a broader role in innate antimicrobial defenses.
摘要
I 型干扰素（IFN），包括 IFN-α 和 IFN-β，是抗病毒免疫反应的关键效应分子。IFN 对病毒感染细胞及其周围组织的抗病毒作用是通过数百种 IFN 刺激基因的表达来介导的。Viperin（病毒抑制蛋白，内质网相关，IFN 诱导）是一种干扰素刺激基因（ISG），可被 I 型、II 型和 III 型 IFN 诱导，或在感染广泛的 DNA 和 RNA 病毒后诱导。最近的证据表明，Viperin 通过破坏脂筏来阻止流感病毒出芽和释放，并通过与参与脂质稳态的小细胞器脂滴结合来干扰丙型肝炎病毒的复制，而这些小细胞器对丙型肝炎病毒的复制至关重要。Viperin 也可被非病毒微生物产物（如脂多糖（LPS））和多种细菌诱导，这表明它在先天抗菌防御中具有更广泛的作用。
相似文献
1
The interferon inducible gene: Viperin.干扰素诱导基因：Viperin。
J Interferon Cytokine Res. 2011 Jan;31(1):131-5. doi: 10.1089/jir.2010.0127. Epub 2010 Dec 12.
2
Viperin Restricts Zika Virus and Tick-Borne Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation.蝰蛇毒素通过靶向NS3进行蛋白酶体降解来限制寨卡病毒和蜱传脑炎病毒的复制。
J Virol. 2018 Mar 14;92(7). doi: 10.1128/JVI.02054-17. Print 2018 Apr 1.
3
Cell-type- and region-specific restriction of neurotropic flavivirus infection by viperin.干扰素诱导跨膜蛋白 Viperin 限制神经亲和性黄病毒感染的细胞和区域特异性。
J Neuroinflammation. 2018 Mar 15;15(1):80. doi: 10.1186/s12974-018-1119-3.
4
Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector.慢性丙型肝炎中ISG表达分析确定蝰蛇毒素为潜在抗病毒效应因子。
Hepatology. 2005 Sep;42(3):702-10. doi: 10.1002/hep.20844.
5
Viperin: a radical response to viral infection.蝰蛇毒蛋白：对病毒感染的一种激进反应。
Biomol Concepts. 2012 Jun;3(3):255-266. doi: 10.1515/bmc-2011-0057.
6
Grouper viperin acts as a crucial antiviral molecule against iridovirus.石斑鱼 viperin 作为一种对抗虹彩病毒的关键抗病毒分子。
Fish Shellfish Immunol. 2019 Mar;86:1026-1034. doi: 10.1016/j.fsi.2018.12.038. Epub 2018 Dec 22.
7
HDV RNA replication is associated with HBV repression and interferon-stimulated genes induction in super-infected hepatocytes.丁型肝炎病毒（HDV）RNA复制与重叠感染的肝细胞中乙肝病毒（HBV）抑制及干扰素刺激基因诱导相关。
Antiviral Res. 2016 Dec;136:19-31. doi: 10.1016/j.antiviral.2016.10.006. Epub 2016 Oct 19.
8
DDX60L Is an Interferon-Stimulated Gene Product Restricting Hepatitis C Virus Replication in Cell Culture.DDX60L是一种干扰素刺激基因产物，可在细胞培养中限制丙型肝炎病毒复制。
J Virol. 2015 Oct;89(20):10548-68. doi: 10.1128/JVI.01297-15. Epub 2015 Aug 12.
9
Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replication.丙型肝炎病毒感染通过人肝内皮细胞诱导自分泌干扰素信号，并释放外泌体，从而抑制病毒复制。
Gastroenterology. 2015 Feb;148(2):392-402.e13. doi: 10.1053/j.gastro.2014.10.040. Epub 2014 Nov 4.
10
How Does Vaccinia Virus Interfere With Interferon?痘苗病毒如何干扰干扰素？
Adv Virus Res. 2018;100:355-378. doi: 10.1016/bs.aivir.2018.01.003. Epub 2018 Feb 16.
引用本文的文献
1
Viperin: A Multifunctional Protein in Antiviral Immunity and Disease Pathogenesis.蝰蛇毒蛋白：抗病毒免疫与疾病发病机制中的一种多功能蛋白。
Pathogens. 2025 May 21;14(5):510. doi: 10.3390/pathogens14050510.
2
Viperin expression leads to downregulation of mitochondrial genes through misincorporation of ddhCTP by mitochondrial RNA polymerase.蝰蛇毒素诱导蛋白（Viperin）的表达通过线粒体RNA聚合酶对双脱氧胞苷三磷酸（ddCTP）的错误掺入导致线粒体基因的下调。
J Biol Chem. 2025 Apr;301(4):108359. doi: 10.1016/j.jbc.2025.108359. Epub 2025 Feb 25.
3
Viperin and Its Effect on SVCV Replication in Common Carp, .蝰蛇毒因子及其对鲤春病毒血症病毒在鲤鱼中复制的影响
Animals (Basel). 2025 Jan 3;15(1):96. doi: 10.3390/ani15010096.
4
RSAD2 suppresses viral replication by interacting with the Senecavirus A 2 C protein.RSAD2 通过与塞内卡病毒 A 2C 蛋白相互作用来抑制病毒复制。
Vet Res. 2024 Sep 27;55(1):115. doi: 10.1186/s13567-024-01370-2.
5
HIV-induced RSAD2/Viperin supports sustained infection of monocyte-derived macrophages.HIV 诱导的 RSAD2/Viperin 支持单核细胞来源的巨噬细胞的持续感染。
J Virol. 2024 Oct 22;98(10):e0086324. doi: 10.1128/jvi.00863-24. Epub 2024 Sep 11.
6
Feasibility of Using a Type I IFN-Based Non-Animal Approach to Predict Vaccine Efficacy and Safety Profiles.使用基于I型干扰素的非动物方法预测疫苗疗效和安全性概况的可行性。
Vaccines (Basel). 2024 May 27;12(6):583. doi: 10.3390/vaccines12060583.
7
Cytosolic DNA sensors activation of human astrocytes inhibits herpes simplex virus through IRF1 induction.细胞质 DNA 传感器激活人星形胶质细胞通过诱导 IRF1 抑制单纯疱疹病毒。
Front Cell Infect Microbiol. 2024 May 14;14:1383811. doi: 10.3389/fcimb.2024.1383811. eCollection 2024.
8
Feedback loop regulation between viperin and viral hemorrhagic septicemia virus through competing protein degradation pathways.通过竞争性蛋白质降解途径实现的蝰蛇毒蛋白与病毒性出血性败血症病毒之间的反馈回路调节
bioRxiv. 2024 Jan 10:2024.01.09.574905. doi: 10.1101/2024.01.09.574905.
9
Dexamethasone impairs the expression of antimicrobial mediators in lipopolysaccharide-activated primary macrophages by inhibiting both expression and function of interferon β.地塞米松通过抑制干扰素 β 的表达和功能来损害脂多糖激活的原代巨噬细胞中抗菌介质的表达。
Front Immunol. 2023 Oct 24;14:1190261. doi: 10.3389/fimmu.2023.1190261. eCollection 2023.
10
Transcriptional responses of liver and spleen in to polyriboinosinic polyribocytidylic acid.聚肌胞苷酸诱导的肝脾转录反应。
Front Immunol. 2023 Oct 13;14:1272393. doi: 10.3389/fimmu.2023.1272393. eCollection 2023.
本文引用的文献
1
Peroxisomes are signaling platforms for antiviral innate immunity.过氧化物酶体是抗病毒先天免疫的信号平台。
Cell. 2010 May 14;141(4):668-81. doi: 10.1016/j.cell.2010.04.018. Epub 2010 May 6.
2
Cellular lipid droplets and hepatitis C virus life cycle.细胞脂滴与丙型肝炎病毒生命周期。
Biol Pharm Bull. 2010;33(3):355-9. doi: 10.1248/bpb.33.355.
3
The antiviral protein viperin is a radical SAM enzyme.抗病毒蛋白 viperin 是一种自由基 SAM 酶。
FEBS Lett. 2010 Mar 19;584(6):1263-7. doi: 10.1016/j.febslet.2010.02.041. Epub 2010 Feb 20.
4
Intracellular DNA recognition.细胞内 DNA 识别。
Nat Rev Immunol. 2010 Feb;10(2):123-30. doi: 10.1038/nri2690.
5
Structural characterization reveals that viperin is a radical S-adenosyl-L-methionine (SAM) enzyme.结构特征表明 viperin 是一种活性 S-腺苷-L-甲硫氨酸（SAM）酶。
Biochem Biophys Res Commun. 2010 Jan 15;391(3):1390-5. doi: 10.1016/j.bbrc.2009.12.070. Epub 2009 Dec 22.
6
The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic alpha-helix.抗病毒蛋白 viperin 通过其 N 端两亲性 α-螺旋定位于脂滴。
Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20452-7. doi: 10.1073/pnas.0911679106. Epub 2009 Nov 17.
7
Amphipathic helices and membrane curvature.两亲性螺旋与膜曲率。
FEBS Lett. 2010 May 3;584(9):1840-7. doi: 10.1016/j.febslet.2009.10.022. Epub 2009 Oct 20.
8
The N-terminal amphipathic alpha-helix of viperin mediates localization to the cytosolic face of the endoplasmic reticulum and inhibits protein secretion.蝰蛇毒蛋白的N端两亲性α螺旋介导其定位于内质网的胞质面并抑制蛋白质分泌。
J Biol Chem. 2009 Feb 13;284(7):4705-12. doi: 10.1074/jbc.M807261200. Epub 2008 Dec 12.
9
Viral evasion and subversion of pattern-recognition receptor signalling.病毒对模式识别受体信号传导的逃避与颠覆
Nat Rev Immunol. 2008 Dec;8(12):911-22. doi: 10.1038/nri2436.
10
The cellular antiviral protein viperin is attenuated by proteasome-mediated protein degradation in Japanese encephalitis virus-infected cells.在日本脑炎病毒感染的细胞中，细胞抗病毒蛋白蝰蛇毒蛋白（viperin）通过蛋白酶体介导的蛋白质降解而被削弱。
J Virol. 2008 Nov;82(21):10455-64. doi: 10.1128/JVI.00438-08. Epub 2008 Sep 3.
Zotero 插件