Université de Nice-Sophia Antipolis and CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France.
FEBS Lett. 2010 May 3;584(9):1840-7. doi: 10.1016/j.febslet.2009.10.022. Epub 2009 Oct 20.
Numerous data have been collected on lipid-binding amphipathic helices involved in membrane-remodeling machineries and vesicular transport. Here we describe how, with regard to lipid composition, the physicochemical features of some amphipathic helices explain their ability to recognize membrane curvature or to participate in membrane remodeling. We propose that sensing highly-curved membranes requires that the polar and hydrophobic faces of the helix do not cooperate in lipid binding. A more detailed description of the interaction between amphipathic helices and lipids is however needed; notably to explain how new helices contribute to detection of modest changes in curvature or even negative curvature.
已经收集了大量涉及膜重塑机制和囊泡运输的与脂类结合的两亲性螺旋的数据。在这里，我们将描述在脂类组成方面，一些两亲性螺旋的物理化学特性如何解释它们识别膜曲率或参与膜重塑的能力。我们提出，感知高度弯曲的膜需要螺旋的极性和疏水面不在脂类结合中合作。然而，需要更详细地描述两亲性螺旋与脂类的相互作用；特别是要解释新的螺旋如何有助于检测曲率的适度变化，甚至负曲率。
