Department of Materials Science & Engineering, Faculty of Engineering, National University of Singapore, Singapore.
Nanomedicine (Lond). 2010 Dec;5(10):1571-84. doi: 10.2217/nnm.10.77.
Superparamagnetic magnetite nanoparticles have been under intensive investigation in nanomedicine. However, it is still a challenge to synthesize high-quality water-stable magnetite nanoparticles for better magnetic performance and less side effects in medical MRI and nanothermotherapy.
MATERIALS & METHODS: We successfully synthesized hydrophilic magnetite nanoparticles through thermal decomposition of Fe(acac)(3) in triethylene glycol, which were coated with a triethylene glycol layer and thus demonstrated excellent water stability.
The optimized deposition temperature has been found to be 250°C (IO-250 NPs). The magnetic and thermal properties as well as the cytotoxicity of IO-250 NPs were investigated. In vitro experiments have demonstrated high cellular uptake and low cytotoxicity. The hyperthermia experiments showed effectiveness in temperature rise and cancer cell death. IO-250 NPs showed promising MRI with relaxivity r(2)* as high as 617.5 s(-1) mM(-1) Fe. In vivo MRI showed excellent tumor imaging.
The IO-250 NPs have great potential to be applied for clinical MRI and magnetic thermotherapy.
超顺磁磁铁矿纳米粒子在纳米医学领域受到了广泛关注。然而，为了获得更好的磁共振成像（MRI）性能和更少的副作用，仍需要合成高质量的水稳定性磁铁矿纳米粒子，以实现更好的磁性能和更少的副作用。
我们通过在三乙二醇中热分解 Fe(acac)(3)成功合成了亲水性磁铁矿纳米粒子，这些纳米粒子表面覆盖有三乙二醇层，因此表现出优异的水稳定性。
发现优化的沉积温度为 250°C（IO-250 NPs）。对 IO-250 NPs 的磁性能、热性能和细胞毒性进行了研究。体外实验表明，其具有较高的细胞摄取率和较低的细胞毒性。在体外热疗实验中，升温效果和癌细胞死亡效果显著。IO-250 NPs 的弛豫率 r(2)*高达 617.5 s(-1) mM(-1) Fe，具有良好的 MRI 性能。体内 MRI 显示出优异的肿瘤成像效果。
IO-250 NPs 具有很大的潜力应用于临床 MRI 和磁热疗。
