State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science & Engineering, Tsinghua University, Beijing, 100084, China.
Advanced Materials of Ministry of Education of China, School of Materials Science & Engineering, Tsinghua University, Beijing, 100084, China.
Theranostics. 2018 May 11;8(12):3284-3307. doi: 10.7150/thno.25220. eCollection 2018.
In the past decade, iron oxide nanoparticles (IONPs) have attracted more and more attention for their excellent physicochemical properties and promising biomedical applications. In this review, we summarize and highlight recent progress in the design, synthesis, biocompatibility evaluation and magnetic theranostic applications of IONPs, with a special focus on cancer treatment. Firstly, we provide an overview of the controlling synthesis strategies for fabricating zero-, one- and three-dimensional IONPs with different shapes, sizes and structures. Then, the and biocompatibility evaluation and biotranslocation of IONPs are discussed in relation to their chemo-physical properties including particle size, surface properties, shape and structure. Finally, we also highlight significant achievements in magnetic theranostic applications including magnetic resonance imaging (MRI), magnetic hyperthermia and targeted drug delivery. This review provides a background on the controlled synthesis, biocompatibility evaluation and applications of IONPs as cancer theranostic agents and an overview of the most up-to-date developments in this area.
在过去的十年中，氧化铁纳米粒子（IONPs）因其优异的物理化学性质和有前途的生物医学应用而引起了越来越多的关注。在这篇综述中，我们总结和强调了 IONPs 的设计、合成、生物相容性评估和磁治疗应用的最新进展，特别关注癌症治疗。首先，我们提供了一种概述，介绍了用于制造具有不同形状、大小和结构的零维、一维和三维 IONPs 的控制合成策略。然后，讨论了 IONPs 的生物相容性评估和生物转位与其化学物理性质的关系，包括粒径、表面性质、形状和结构。最后，我们还强调了在磁治疗应用方面的重要成就，包括磁共振成像（MRI）、磁热疗和靶向药物输送。这篇综述提供了作为癌症治疗剂的 IONPs 的受控合成、生物相容性评估和应用的背景，并概述了该领域的最新发展。
