Health Protection Surveillance Centre, Health Service Executive, Dublin, Ireland.
Crit Care Resusc. 2010 Dec;12(4):255-61.
To describe the incidence, clinical characteristics and outcomes of critically ill patients in Ireland with pandemic (H1N1) 2009 infection, and to provide a dynamic assessment of the burden of such cases on Irish intensive care units.
DESIGN, SETTING AND PARTICIPANTS: Multicentre prospective observational study of all adult patients admitted to any of the 30 ICUs in the Republic of Ireland between 15 July 2009 and 30 May 2010.
Patient demographics, clinical characteristics and ICU mortality; ICU admissions, bed-days, bed occupancy rates and distribution.
Seventy-seven adult patients with pandemic (H1N1) 2009 infection were admitted to 27 of 30 Irish ICUs. The median age was 43 years (IQR, 30-56 years); 67 patients (88%) were aged under 65; 39 (51%) were male. Sixty-two patients (82%) had comorbid conditions, including obesity (36%), respiratory disease (34%) and malignancy or immunosuppression (20%). Eight (11%) were pregnant, and 27 (36%) were smokers. Sixty-seven patients were mechanically ventilated, 24 (32%) required renal replacement therapy, 39 (51%) received vasopressors and four (5%) received extracorporeal membrane oxygenation. Of 14 patients (18%) who died in the ICU, two had no pre-existing comorbidities. The ICU admission rate of patients with pandemic (H1N1) 2009 infection was 22.5/million population. A total of 1882 ICU bed-days (557.5 bed-days/million adult population) were consumed, equating to a 3.9% bed occupancy rate, with a peak of 14.0% in October 2009. Median length of stay was 12 days (IQR, 7-34 days).
The 2009 influenza A (H1N1) pandemic was a significant burden on Irish ICUs, predominantly affecting the tertiary centres. The demographics and clinical characteristics were similar to those described in the southern hemisphere, suggesting such data may inform future resource planning for similar threats.
描述 2009 年大流行（H1N1）流感感染的危重病患者在爱尔兰的发病率、临床特征和结局，并对爱尔兰重症监护病房此类病例的负担进行动态评估。
设计、地点和参与者：这是一项对 2009 年 7 月 15 日至 2010 年 5 月 30 日期间共和国的 30 家重症监护病房（ICU）中任何一家收治的所有成年患者进行的多中心前瞻性观察性研究。
患者人口统计学、临床特征和 ICU 死亡率；ICU 入院人数、床日数、床位占用率和分布。
77 例 2009 年大流行（H1N1）流感感染的成年患者被收入爱尔兰 30 家 ICU 中的 27 家。中位年龄为 43 岁（IQR，30-56 岁）；67 名患者（88%）年龄小于 65 岁；39 名（51%）为男性。62 名患者（82%）合并有合并症，包括肥胖（36%）、呼吸系统疾病（34%）和恶性肿瘤或免疫抑制（20%）。8 名（11%）为孕妇，27 名（36%）为吸烟者。67 名患者需要机械通气，24 名（32%）需要肾脏替代治疗，39 名（51%）接受血管加压素治疗，4 名（5%）接受体外膜氧合治疗。在 ICU 死亡的 14 名患者中（18%），有 2 名患者没有预先存在的合并症。2009 年流感 A（H1N1）大流行期间，接受 ICU 治疗的患者的发病率为 22.5/百万人口。共消耗了 1882 个 ICU 床日（557.5 个床日/百万成年人口），床位占用率为 3.9%，2009 年 10 月达到峰值 14.0%。中位住院时间为 12 天（IQR，7-34 天）。
2009 年甲型 H1N1 流感大流行对爱尔兰 ICU 造成了重大负担，主要影响三级中心。人口统计学和临床特征与南半球描述的相似，这表明此类数据可能为未来应对类似威胁的资源规划提供信息。
