Pontinen Thomas, Melin Alyson, Varadi Gabor, Khanmoradi Kamran, Chewaproug Daranee, Kung Shiang Cheng, Zaki Radi, Ortiz Jorge
Department of Surgery, Albert Einstein Medical Center, Philadelphia, PA, USA.
Exp Clin Transplant. 2010 Dec;8(4):273-6.
Pancreatic cancer is one of the most lethal human cancers. Each year in the United States, about 42 470 individuals are diagnosed with this condition, and 35 240 die, despite advances in imaging, medical treatment, and surgical intervention. Often, 80% to 90% of pancreatic cancers are diagnosed at the locally advanced or metastatic stage. However, cutaneous metastases originating from pancreatic cancer are rare. If cutaneous metastases do indeed occur, it is often near the umbilicus, known as the Sister Mary Joseph's nodule. Nonumblical cutaneous metastases are rare, with only several cases reported, but none regarding lesions after organ transplant. We introduce the first reported case of a cutaneous metastatic lesion of pancreatic adenocarcinoma after the transplant of an organ. We also performed a literature review and an analysis of reported cases of nonumblical cutaneous metastases of pancreatic adenocarcinoma.
We performed a MEDLINE and PubMed search of reported nonumblical cutaneous metastases of pancreatic adenocarcinoma since 1980 after a literature review and analysis.
Our case involved a 76-year-old woman who developed cutaneous pancreatic adenocarcinoma metastases in her surgical wound 2 years after a bilateral kidney transplant. This is the first case of pancreatic adenocarcinoma cutaneous metastases after an organ transplant.
The death rate from cancer has increased as the population has aged. This also holds true for transplant recipients. Some believe that cancer will soon surpass cardiovascular disease as the major cause of mortality after transplant. Therefore, it is incumbent upon us to appropriately screen patients with age-appropriate evidence-based examinations. Additionally, those patients with suspicious presentations should be judiciously evaluated to discover a cure for cancer as quickly as possible.
胰腺癌是最致命的人类癌症之一。在美国，尽管在影像学、药物治疗和手术干预方面取得了进展，但每年仍有约42470人被诊断出患有这种疾病，35240人死亡。通常，80%至90%的胰腺癌在局部晚期或转移阶段被诊断出来。然而，源自胰腺癌的皮肤转移很少见。如果确实发生皮肤转移，通常发生在脐周，即所谓的玛丽·约瑟夫修女结节。非脐周皮肤转移很少见，仅有几例报告，但没有关于器官移植后病变的报告。我们介绍了首例器官移植后胰腺腺癌皮肤转移病变的报告病例。我们还对已报告的胰腺腺癌非脐周皮肤转移病例进行了文献综述和分析。
在进行文献综述和分析后，我们对1980年以来报告的胰腺腺癌非脐周皮肤转移病例进行了MEDLINE和PubMed检索。
我们的病例涉及一名76岁女性，她在双侧肾移植2年后手术伤口处出现了胰腺腺癌皮肤转移。这是器官移植后胰腺腺癌皮肤转移的首例病例。
随着人口老龄化，癌症死亡率有所上升。移植受者也是如此。一些人认为，癌症很快将超过心血管疾病，成为移植后主要的死亡原因。因此，我们有责任通过适合患者年龄的循证检查进行适当筛查。此外，对于那些表现可疑的患者，应进行审慎评估，以便尽快找到癌症的治疗方法。
