Shi Ying, Li Shan-Shan, Liu Dan-Yan, Yu Yan
Department of Dermatology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Department of Dermatology and Venereology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
World J Gastrointest Oncol. 2020 Nov 15;12(11):1372-1380. doi: 10.4251/wjgo.v12.i11.1372.
Cutaneous metastases originating from pancreatic cancer are relatively rare. The most common reported site of metastasis is the umbilicus, and this manifestation is known as the Sister Mary Joseph's nodule. Non-umbilical cutaneous metastases are far less common, with only a few cases reported in the literature. Our case is the first case report, to our knowledge, on metastasis involving the labia majora and flat papules.
A 49-year-old Chinese female patient presented with a number of red, swollen papules on the vulva for 2 mo. Histological examination of the labia majora lesion revealed metastatic adenocarcinoma. The serum levels of tumor biomarkers CA199, CA242, and CA125 were significantly elevated. B-mode ultrasound-guided needle biopsy of the pancreas demonstrated moderately and poorly differentiated adenocarcinoma. The patient finally declined treatment for financial reasons and died 3 mo later.
Metastatic cutaneous lesions could indicate pancreatic cancer. Serum levels of tumor biomarkers may aid in diagnosing metastatic pancreatic adenocarcinoma.
源自胰腺癌的皮肤转移相对罕见。报道的最常见转移部位是脐部，这种表现被称为玛丽·约瑟夫修女结节。非脐部皮肤转移极为少见，文献中仅报道了少数病例。据我们所知，我们的病例是首例关于累及大阴唇和平坦丘疹转移的病例报告。
一名49岁中国女性患者，外阴出现多个红肿丘疹2个月。大阴唇病变的组织学检查显示为转移性腺癌。肿瘤生物标志物CA199、CA242和CA125的血清水平显著升高。B超引导下胰腺穿刺活检显示为中低分化腺癌。患者最终因经济原因拒绝治疗，3个月后死亡。
皮肤转移性病变可能提示胰腺癌。肿瘤生物标志物的血清水平可能有助于诊断转移性胰腺腺癌。
