Department of Oral Diagnosis and Surgery, Araraquara Dental School - UNESP, University of Estadual Paulista, Araraquara, São Paulo, São Paulo, BrazilBone Metabolism Laboratory of Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Clin Oral Implants Res. 2011 Jul;22(7):716-721. doi: 10.1111/j.1600-0501.2010.02046.x. Epub 2010 Dec 9.
This study evaluated the effect of magnesium dietary deficiency on bone metabolism and bone tissue around implants with established osseointegration.
For this, 30 rats received an implant in the right tibial metaphysis. After 60 days for healing of the implants, the animals were divided into groups according to the diet received. Control group (CTL) received a standard diet with adequate magnesium content, while test group (Mg) received the same diet except for a 90% reduction of magnesium. The animals were sacrificed after 90 days for evaluation of calcium, magnesium, osteocalcin and parathyroid hormone (PTH) serum levels and the deoxypyridinoline (DPD) level in the urine. The effect of magnesium deficiency on skeletal bone tissue was evaluated by densitometry of the lumbar vertebrae, while the effect of bone tissue around titanium implants was evaluated by radiographic measurement of cortical bone thickness and bone density. The effect on biomechanical characteristics was verified by implant removal torque testing.
Magnesium dietary deficiency resulted in a decrease of the magnesium serum level and an increase of PTH and DPD levels (P ≤ 0.05). The Mg group also presented a loss of systemic bone mass, decreased cortical bone thickness and lower values of removal torque of the implants (P ≤ 0.01).
The present study concluded that magnesium-deficient diet had a negative influence on bone metabolism as well as on the bone tissue around the implants.
本研究评估了镁饮食缺乏对已建立骨整合的植入物周围骨代谢和骨组织的影响。
为此，30 只大鼠在右侧胫骨干骺端植入了一枚植入物。在植入物愈合 60 天后，根据所接受的饮食将动物分为两组。对照组（CTL）接受含有足够镁含量的标准饮食，而实验组（Mg）接受相同的饮食，但镁含量减少 90%。90 天后，处死动物以评估血清钙、镁、骨钙素和甲状旁腺激素（PTH）水平以及尿液中的脱氧吡啶啉（DPD）水平。通过腰椎骨密度测定评估镁缺乏对骨骼骨组织的影响，通过皮质骨厚度和骨密度的放射测量评估钛植入物周围骨组织的影响。通过植入物去除扭矩测试验证对生物力学特性的影响。
镁饮食缺乏导致血清镁水平降低，PTH 和 DPD 水平升高（P ≤ 0.05）。Mg 组还表现出全身骨量丢失、皮质骨厚度减少和植入物去除扭矩值降低（P ≤ 0.01）。
本研究表明，镁缺乏饮食对骨代谢以及植入物周围的骨组织有负面影响。
