Mother and Infant Research Unit, The University of York, Department of Health Sciences, Area 4, Seebohm Rowntree Building, Heslington, York, North Yorkshire YO10 5DD, UK.
Matern Child Nutr. 2011 Jan;7(1):3-26. doi: 10.1111/j.1740-8709.2010.00284.x.
Determining early-life risk factors for obesity in later life is essential in order to effectively target preventative interventions to reduce obesity. The aim of this systematic review was to investigate current evidence to determine whether the timing of introducing solid foods is associated with obesity in infancy and childhood. Relevant randomized and observational studies from developed countries were identified by searching the following six bio-medical databases (Medline, Embase, British Nursing Index, CINAHL, Maternity and Infant Care, and PsycINFO) and hand-searching reference lists. Studies of pre-term or low birthweight infants were excluded. Twenty-four studies met the inclusion criteria for the systematic review. Data from over 34,000 participants were available for interpretative analysis. No clear association between the age of introduction of solid foods and obesity was found. It is likely that a whole family approach to obesity prevention will be most effective and health professionals should continue to promote healthy infant feeding in line with national recommendations.
确定生命早期肥胖的风险因素对于有效针对预防干预以减少肥胖至关重要。本系统综述的目的是调查当前的证据，以确定固体食物引入的时间是否与婴儿期和儿童期肥胖有关。通过搜索以下六个生物医学数据库（Medline、Embase、英国护理索引、CINAHL、母婴保健和心理信息中心）和手检参考文献，确定了来自发达国家的相关随机和观察性研究。排除了早产儿或低出生体重儿的研究。有 24 项研究符合系统综述的纳入标准。可用于解释性分析的数据来自超过 34000 名参与者。固体食物引入的年龄与肥胖之间似乎没有明确的关联。预防肥胖最有效的方法可能是整个家庭的方法，并且医疗保健专业人员应继续按照国家建议促进健康的婴儿喂养。
