Reikvam H, van de Watering L, Prowse C, Devine D, Heddle N M, Hervig T
Department of Haematology, Institute of Internal Medicine, University of Bergen, Bergen, Norway.
Transfus Med. 2011 Jun;21(3):145-9. doi: 10.1111/j.1365-3148.2010.01059.x. Epub 2010 Dec 12.
Red blood cell concentrates (RCCs) are the major blood component transfused to patients. There is a great variability in patient response, depending on both the patient's blood volume and haemoglobin content in the RCC. Standardisation of transfusion practice is needed to improve the prediction of patient outcome.
We hypothesise that labelling of RCCs with haemoglobin content will add possibilities for the standardisation of transfusion practice.
Data from multiple international transfusion services regarding haemoglobin content and weight or volume of RCC were collected and analysed.
We demonstrate a strong and highly significant correlation between haemoglobin content with both weight and volume of the RCCs. A linear regression model was used to assess these relationships, and it demonstrates how haemoglobin content can be estimated for different cell production processes.
We recommend the use of weight or volume of the RCCs as the basis of estimating haemoglobin in the RCC and postulate that this can be used in future studies to explore the effects of a haemoglobin dose-based transfusion system. As the weight - and sometimes the volume - of the blood bag is easily accessible, in contrast to direct haemoglobin measurements from each individual unit, this method is feasible and simple.
红细胞浓缩液（RCCs）是输注给患者的主要血液成分。患者的反应存在很大差异，这取决于患者的血容量和RCC中的血红蛋白含量。需要对输血实践进行标准化，以改善对患者预后的预测。
我们假设用血红蛋白含量标记RCCs将增加输血实践标准化的可能性。
收集并分析了来自多个国际输血服务机构的有关RCCs血红蛋白含量及重量或体积的数据。
我们证明了RCCs的血红蛋白含量与重量和体积之间存在强且高度显著的相关性。使用线性回归模型评估这些关系，并展示了如何针对不同的细胞生产过程估算血红蛋白含量。
我们建议以RCCs的重量或体积作为估算RCC中血红蛋白的基础，并假定这可用于未来研究，以探索基于血红蛋白剂量的输血系统的效果。与直接测量每个单位的血红蛋白相比，血袋的重量（有时还有体积）很容易获取，因此该方法可行且简单。
