National University of Ireland, Galway, Ireland.
Br J Gen Pract. 2010 Dec;60(581):e476-88. doi: 10.3399/bjgp10X544113.
Patients with high blood pressure (hypertension) in the community frequently fail to meet treatment goals: a condition labelled as 'uncontrolled' hypertension. The optimal way to organise and deliver care to hypertensive patients has not been clearly identified.
To determine the effectiveness of interventions to improve control of blood pressure in patients with hypertension.
Systematic review of randomised controlled trials.
Primary and ambulatory care.
Interventions were categorised as following: self-monitoring; educational interventions directed to the patient; educational interventions directed to the health professional; health professional- (nurse or pharmacist) led care; organisational interventions that aimed to improve the delivery of care; and appointment reminder systems. Outcomes assessed were mean systolic and diastolic blood pressure, control of blood pressure and proportion of patients followed up at clinic.
Seventy-two RCTs met the inclusion criteria. The trials showed a wide variety of methodological quality. Self-monitoring was associated with net reductions in systolic blood pressure (weighted mean difference [WMD] -2.5 mmHg, 95%CI = -3.7 to -1.3 mmHg) and diastolic blood pressure (WMD -1.8 mmHg, 95%CI = -2.4 to -1.2 mmHg). An organised system of regular review allied to vigorous antihypertensive drug therapy was shown to reduce blood pressure and all-cause mortality in a single large randomised controlled trial.
Antihypertensive drug therapy should be implemented by means of a vigorous stepped care approach when patients do not reach target blood pressure levels. Self-monitoring is a useful adjunct to care while reminder systems and nurse/pharmacist -led care require further evaluation.
社区中患有高血压(高血压)的患者经常无法达到治疗目标:这种情况被称为“未控制”的高血压。尚未明确确定组织和提供高血压患者护理的最佳方法。
确定改善高血压患者血压控制的干预措施的有效性。
系统评价随机对照试验。
初级保健和门诊。
干预措施分为以下几类:自我监测;针对患者的教育干预;针对卫生专业人员的教育干预;由卫生专业人员(护士或药剂师)领导的护理;旨在改善护理提供的组织干预措施;以及预约提醒系统。评估的结果是平均收缩压和舒张压、血压控制以及在诊所随访的患者比例。
符合纳入标准的 72 项 RCT。这些试验显示出方法学质量的广泛差异。自我监测与收缩压(加权均数差 [WMD] -2.5mmHg,95%CI = -3.7 至 -1.3mmHg)和舒张压(WMD -1.8mmHg,95%CI = -2.4 至 -1.2mmHg)的净降低相关。一项针对常规定期审查与强化抗高血压药物治疗相结合的大型随机对照试验表明,这可以降低血压和全因死亡率。
当患者未达到目标血压水平时,应通过强化阶梯式治疗方法实施抗高血压药物治疗。自我监测是护理的有用辅助手段,而提醒系统和护士/药剂师主导的护理需要进一步评估。