Halme Laura, Vesalainen Risto, Kaaja Mika, Kantola Ilkka
Department of Medicine, Turku University Hospital, Turku, Finland.
Am J Hypertens. 2005 Nov;18(11):1415-20. doi: 10.1016/j.amjhyper.2005.05.017.
The majority of hypertensive patients do not reach the target blood pressure (BP). We sought to clarify whether intermittent self-monitoring of BP leads to better BP control compared to ordinary treatment in general practice.
Two hundred sixty-nine hypertensive patients participated in this multicenter, randomized, parallel-group study in primary health care. Home BP was measured in the self-monitoring (SM) group at 0, 2, 4, and 6 months, and in the control (C) group at 0 and 6 months. The participating physicians were instructed to intensify the antihypertensive therapy when needed.
At the beginning, both groups had similar home BP levels (SM 143.1 +/- 17.4/85.3 +/- 7.4 mm Hg v C 143.9 +/- 18.3/85.4 +/- 7.5 mm Hg). After 6 months, there were significant decreases in systolic (P <or= .0001), diastolic (P <or= .0029), and pulse pressures (P <or= .021) in both groups. Systolic (-7.8 +/- 13.1 mm Hg v -4.5 +/- 12.2 mm Hg, P = .047) and pulse pressure (-4.7 +/- 9.0 mm Hg v -2.2 +/- 10.0 mm Hg, P = .042) decreased significantly more than in the self-monitoring group. The decrease in diastolic pressure was similar in both groups (SM -3.1 +/- 6.2 mm Hg v C -2.3 +/- 8.3 mm Hg, P = not significant). The patients in the SM group reached home BP target more often than those in the C group (29% v 16%, P = .016). There was a nonsignificant trend toward lower office BP values in the SM group.
Self-monitoring decreased systolic and pulse pressure significantly more than ordinary treatment and promoted achievement of target BP. This was most likely due to improved patient compliance and more active treatment by the physicians. Our results suggest that home measurement is useful in the control of hypertension.
大多数高血压患者未达到目标血压(BP)。我们试图阐明,在全科医疗中,与常规治疗相比,间歇性自我血压监测是否能更好地控制血压。
269名高血压患者参与了这项在初级卫生保健机构进行的多中心、随机、平行组研究。自我监测(SM)组在0、2、4和6个月时测量家庭血压,对照组(C组)在0和6个月时测量。指导参与的医生在需要时加强抗高血压治疗。
开始时,两组的家庭血压水平相似(SM组为143.1±17.4/85.3±7.4 mmHg,C组为143.9±18.3/85.4±7.5 mmHg)。6个月后,两组的收缩压(P≤0.0001)、舒张压(P≤0.0029)和脉压(P≤0.021)均显著下降。收缩压(-7.8±13.1 mmHg对-4.5±12.2 mmHg,P = 0.047)和脉压(-4.7±9.0 mmHg对-2.2±10.0 mmHg,P = 0.042)下降幅度明显大于自我监测组。两组舒张压下降幅度相似(SM组为-3.1±6.2 mmHg,C组为-2.3±8.3 mmHg,P无统计学意义)。SM组患者达到家庭血压目标的比例高于C组(29%对16%,P = 0.016)。SM组诊室血压值有降低的趋势,但无统计学意义。
自我监测使收缩压和脉压下降幅度明显大于常规治疗,并促进了目标血压的实现。这很可能是由于患者依从性提高和医生更积极的治疗。我们的结果表明,家庭血压测量对高血压控制有用。