Rhinology Unit, General and University Hospital and Medical Center, Valencia, Spain.
Am J Rhinol Allergy. 2010 Nov-Dec;24(6):413-5. doi: 10.2500/ajra.2010.24.3549.
Eosinophils are possibly the most important inflammatory cells in the pathogenesis of chronic rhinosinusitis with nasal polyposis. Eosinophilic nasal mucosal infiltration is characteristic of nasal polyposis. The aim of this work was to study the possibility of correlations between cytological and tissue eosinophilia in patients with nasal polyposis and with the stage of the disease. If this correlation exists, nasal cytology will be very useful in diagnosis and management of patients with nasal polyposis.
We studied 40 patients affected idiopathic nasal polyposis and 12 normal group controls. Qualitative measurements of eosinophils in nasal exudates and in tissue biopsy specimens were performed and the results were compared.
Nasal cytology and tissue biopsy showed a statistical correlation in the normal as well as in the pathological group. Clinical staging polyposis also correlated with cytological and tissue eosinophilia.
Nasal cytological eosinophilia is a simple, fast, nontraumatic, and inexpensive method in the evaluation of patients with nasal polyposis. Eosinophilic infiltration of the nasal mucosa is characteristic of nasal polyposis. It correlates with the stage of the disease and tends to be higher in patients with asthma, nasal polyposis, and nonsteroidal anti-inflammatory drug intolerance (acetyl-salicylic acid triad).
嗜酸性粒细胞可能是慢性鼻-鼻窦炎伴鼻息肉发病机制中最重要的炎症细胞。嗜酸性鼻黏膜浸润是鼻息肉的特征。本研究的目的是研究鼻息肉患者和疾病分期的细胞学和组织嗜酸性粒细胞之间存在相关性的可能性。如果存在这种相关性，鼻细胞学检查将对鼻息肉患者的诊断和治疗非常有用。
我们研究了 40 例特发性鼻息肉患者和 12 例正常对照组。对鼻分泌物和组织活检标本中的嗜酸性粒细胞进行定性测量，并比较结果。
鼻细胞学和组织活检在正常组和病理组均显示出统计学相关性。息肉的临床分期也与细胞学和组织嗜酸性粒细胞相关。
鼻细胞学嗜酸性粒细胞增多是评估鼻息肉患者的一种简单、快速、非创伤性且廉价的方法。鼻黏膜嗜酸性粒细胞浸润是鼻息肉的特征。它与疾病的阶段相关，并且在哮喘、鼻息肉和非甾体抗炎药不耐受（乙酰水杨酸三联征）的患者中倾向于更高。
