Sexually Transmitted Bacteria Reference Laboratory, Health Protection Agency, London, United Kingdom.
Euro Surveill. 2011 Apr 7;16(14):19833.
Successful treatment of gonorrhoea is the mainstay of public health control. Cefixime and ceftriaxone, highly active third generation cephalosporins, are today the recommended first-line agents in most countries and azithromycin is a second-line agent. However, there is increasing evidence of decreasing susceptibility and emergence of therapeutic failures. In this report two cases of clinical failure to cefixime are described, one of which additionally shows failure to azithromycin and selection of a less susceptible strain during treatment.
成功治疗淋病是公共卫生控制的主要手段。头孢克肟和头孢曲松，高效的第三代头孢菌素，是目前大多数国家推荐的一线药物，而阿奇霉素是二线药物。然而，越来越多的证据表明其敏感性降低和治疗失败的出现。在本报告中，描述了两例头孢克肟临床治疗失败的病例，其中一例还显示阿奇霉素治疗失败和治疗过程中选择了敏感性较低的菌株。
