Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
Environ Res. 2011 Jan;111(1):81-6. doi: 10.1016/j.envres.2010.11.007. Epub 2010 Dec 7.
We sought to ascertain whether asthmatic children are more likely to have elevated blood lead levels (EBLLs), BLLs ≥ 10 μg/dL, than non-asthmatic children. Household risk factors associated with both lead and asthma were examined.
We undertook a cross-sectional study involving children residing in mainly low-income and minority households in Michigan which were identified by the Statewide Systemic Tracking of Elevated Lead Levels and Remediation database (STELLAR) (n=356 children).
Of the 356 index children, 19% had EBLLs and 15% were doctor-diagnosed asthmatic. After adjusting for confounders known to be related to lead poisoning and/or asthma, association remained between asthmatic children and EBLL children (AOR: 5.17; 95% CI (1.25-21.37)).
The results of our study show that asthmatic children are over 5 times more likely to have EBLLs than non-asthmatics (AOR: 5.17; 95% CI (1.25-21.37)). Intervention strategies designed to address lead poisoning prevention may be effective in reducing incidence of asthma. Further study is required.
我们旨在确定哮喘儿童是否比非哮喘儿童更有可能出现血铅水平升高（BLL≥10μg/dL）。我们研究了与铅和哮喘都相关的家庭危险因素。
我们进行了一项横断面研究，研究对象为密歇根州主要居住在低收入和少数族裔家庭中的儿童，这些家庭是通过全州系统跟踪血铅升高和补救数据库（STELLAR）确定的（n=356 名儿童）。
在 356 名索引儿童中，19%有 EBLL，15%被诊断为哮喘。在调整已知与铅中毒和/或哮喘相关的混杂因素后，哮喘儿童与 EBLL 儿童之间仍存在关联（AOR：5.17；95%CI（1.25-21.37））。
我们的研究结果表明，哮喘儿童出现 EBLL 的可能性是非哮喘儿童的 5 倍以上（AOR：5.17；95%CI（1.25-21.37））。旨在解决铅中毒预防的干预策略可能有助于降低哮喘发病率。需要进一步研究。
