Mohammed Ahmed Abdullah, Mohamed Faisal Yosef, El-Okda El-Sayed, Ahmed Adel Besheer
Departments of Pediatrics and *Community medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Correspondence to: Dr Ahmed Abdullah Mohammed, Assistant Professor of Pediatrics, Ain Shams University, Faculty of Medicine, Abbassia, Cairo Egypt. PO Box 11566.
Indian Pediatr. 2015 Apr;52(4):303-6. doi: 10.1007/s13312-015-0628-8.
To measure blood lead levels in children (5-14 y) with bronchial asthma, and correlate with asthma severity.
Cross-sectional analytical.
Pediatric Allergy and Immunology Clinic of a Childrens hospital in Cairo, Egypt.
200 children (127 males) with bronchial asthma and 125 age- and sex-matched healthy controls (80 males).
Blood lead levels were measured by atomic absorption spectrophotometer technique, and were subsequently correlated with asthma severity.
No significant difference in mean (SD) blood lead levels was observed between children with asthma [13.3 (4.8) ug/dL] and control group [11.4 (3.9) ug/dL]. 190 children (58.5%) had elevated blood lead levels (>10 ug/dL), with no significant difference between patients (60%) and controls (56%). Patients with elevated blood lead levels had significantly higher frequency of eosinophilia (66.7%) and increased total immunoglobulin E (83.3%) compared to other patients with blood lead levels <10ug/dL (10% and 43.8%, respectively). Patients of asthma with elevated blood lead levels had higher grades of severity of asthma compared to those with blood lead levels <10 ug/dL.
Blood lead levels are not significantly associated with diagnosis of asthma but elevated blood lead levels seem to be associated with increased asthma severity and higher frequency of eosinophilia and elevated immunoglobulin E levels.
测量支气管哮喘患儿（5 - 14岁）的血铅水平，并将其与哮喘严重程度相关联。
横断面分析。
埃及开罗一家儿童医院的儿科过敏与免疫诊所。
200名支气管哮喘患儿（127名男性）和125名年龄及性别匹配的健康对照者（80名男性）。
采用原子吸收分光光度计技术测量血铅水平，随后将其与哮喘严重程度相关联。
哮喘患儿[13.3（4.8）μg/dL]与对照组[11.4（3.9）μg/dL]的平均（标准差）血铅水平无显著差异。190名儿童（58.5%）血铅水平升高（>10μg/dL），患者（60%）与对照组（56%）之间无显著差异。与血铅水平<10μg/dL的其他患者相比（分别为10%和43.8%），血铅水平升高的患者嗜酸性粒细胞增多症发生率显著更高（66.7%）且总免疫球蛋白E升高（83.3%）。血铅水平升高的哮喘患者哮喘严重程度等级高于血铅水平<10μg/dL的患者。
血铅水平与哮喘诊断无显著关联，但血铅水平升高似乎与哮喘严重程度增加、嗜酸性粒细胞增多症发生率更高以及免疫球蛋白E水平升高有关。
