Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.
Int J Oral Maxillofac Surg. 2011 Mar;40(3):292-7. doi: 10.1016/j.ijom.2010.10.026. Epub 2010 Dec 8.
In this study, 53 patients received piroxicam, administered orally or sublingually, after undergoing removal of symmetrically positioned lower third molars, during two separate appointments. This study used a randomized, blind, cross-over protocol. Objective and subjective parameters were recorded for comparison of postoperative results for 7 days after surgery. Patients treated with oral or sublingual piroxicam reported low postoperative pain scores. The patients who received piroxicam orally took a similar average amount of analgesic rescue medication compared with patients who received piroxicam sublingually (p>0.05). Patients exhibited similar values for mouth opening measured just before surgery and immediately following suture removal 7 days later (p>0.05), and showed no significant differences between routes of piroxicam administration for swelling control during the second or seventh postoperative days (p>0.05). In summary, pain, trismus and swelling after lower third molar extraction, independent of surgical difficulty, could be controlled by piroxicam 20mg administered orally or sublingually and no significant differences were observed between the route of delivery used in this study.
在这项研究中，53 名患者在接受双侧下颌第三磨牙拔除术后，分别口服或舌下给予吡罗昔康。本研究采用随机、双盲、交叉设计方案。术后 7 天记录客观和主观参数，比较术后结果。口服或舌下给予吡罗昔康的患者报告术后疼痛评分较低。与舌下给予吡罗昔康的患者相比，口服吡罗昔康的患者使用平均等效剂量的镇痛药解救药物（p>0.05）。手术前和术后 7 天拆线时测量张口度，患者的张口度相似（p>0.05），并且在术后第 2 天和第 7 天肿胀控制方面，两种途径使用吡罗昔康无显著差异（p>0.05）。总之，无论手术难度如何，口服或舌下给予 20mg 吡罗昔康均可控制下颌第三磨牙拔除术后的疼痛、牙关紧闭和肿胀，且本研究中使用的两种途径之间无显著差异。
