Australian and New Zealand Intensive Care - Research Centre, Monash University, Melbourne, Victoria 3004, Australia.
Injury. 2011 Mar;42(3):281-7. doi: 10.1016/j.injury.2010.11.047. Epub 2010 Dec 8.
Traumatic brain injury (TBI) is a major public health issue, which results in significant mortality and long term disability. The profound impact of TBI is not only felt by the individuals who suffer the injury but also their care-givers and society as a whole. Clinicians and researchers require reliable and valid measures of long term outcome not only to truly quantify the burden of TBI and the scale of functional impairment in survivors, but also to allow early appropriate allocation of rehabilitation supports. In addition, clinical trials which aim to improve outcomes in this devastating condition require high quality measures to accurately assess the impact of the interventions being studied. In this article, we review the properties of an ideal measure of outcome in the TBI population. Then, we describe the key components and performance of the measurement tools most commonly used to quantify outcome in clinical studies in TBI. These measurement tools include: the Glasgow Outcome Scale (GOS) and extended Glasgow Outcome Scale (GOSe); Disability Rating Scale (DRS); Functional Independence Measure (FIM); Functional Assessment Measure (FAM); Functional Status Examination (FSE) and the TBI-specific and generic quality of life measures used in TBI patients (SF-36 and SF-12, WHOQOL-BREF, SIP, EQ-5D, EBIQ, and QOLIBRI).
创伤性脑损伤 (TBI) 是一个主要的公共卫生问题，导致了显著的死亡率和长期残疾。TBI 的深远影响不仅体现在遭受伤害的个体身上，也体现在他们的照顾者和整个社会身上。临床医生和研究人员需要可靠和有效的长期预后衡量标准，不仅要真正量化 TBI 的负担和幸存者的功能障碍程度，还要允许早期适当分配康复支持。此外，旨在改善这种毁灭性疾病结局的临床试验需要高质量的措施来准确评估正在研究的干预措施的影响。在本文中，我们回顾了 TBI 人群中理想预后衡量标准的特性。然后，我们描述了在 TBI 临床研究中最常用于量化结局的测量工具的关键组成部分和性能。这些测量工具包括：格拉斯哥结局量表 (GOS) 和扩展格拉斯哥结局量表 (GOSe)；残疾评定量表 (DRS)；功能独立性测量 (FIM)；功能评估量表 (FAM)；功能状态检查 (FSE) 和用于 TBI 患者的 TBI 特异性和一般性生活质量测量工具 (SF-36 和 SF-12、WHOQOL-BREF、SIP、EQ-5D、EBIQ 和 QOLIBRI)。
