Department of Medical Psychology and Medical Sociology, Georg-August-University, Goettingen, Germany.
J Neurotrauma. 2010 Jul;27(7):1157-65. doi: 10.1089/neu.2009.1077.
The QOLIBRI (Quality of Life after Brain Injury) is a novel health-related quality-of-life (HRQoL) instrument specifically developed for traumatic brain injury (TBI). It provides a profile of HRQoL in six domains together with an overall score. Scale validity and factors associated with HRQoL were investigated in a multi-center international study. A total of 795 adults with brain injury were studied from 3 months to 15 years post-injury. The majority of participants (58%) had severe injuries as assessed by 24-h worst Glasgow Coma Scale (GCS) score. Systematic relationships were observed between the QOLIBRI and the Glasgow Outcome Scale-Extended (GOSE), Hospital Anxiety and Depression Scale (HADS), and SF-36. Within each scale patients with disability reported having low HRQoL in two to three times as many areas as those who had made a good recovery. The main correlates of the total QOLIBRI score were emotional state (HADS depression and anxiety), functional status (amount of help needed and outcome on the GOSE), and comorbid health conditions. Together these five variables accounted for 58% of the variance in total QOLIBRI scores. The QOLIBRI is the first tool developed to assess disease-specific HRQoL in brain injury, and it contains novel information not given by other currently available assessments.
QOLIBRI（脑损伤后生活质量）是一种专门为创伤性脑损伤（TBI）开发的新型健康相关生活质量（HRQoL）工具。它提供了六个领域的 HRQoL 概况以及总体评分。在一项多中心国际研究中，研究了 QOLIBRI 的量表有效性及其与 HRQoL 相关的因素。共有 795 名脑损伤成年人在受伤后 3 个月至 15 年内接受了研究。大多数参与者（58%）的 24 小时最差格拉斯哥昏迷量表（GCS）评分评估为严重损伤。QOLIBRI 与格拉斯哥结局量表扩展版（GOSE）、医院焦虑和抑郁量表（HADS）和 SF-36 之间观察到系统关系。在每个量表中，残疾患者报告在两到三个方面的 HRQoL 较低，而那些恢复良好的患者则报告在这些方面的 HRQoL 较低。总 QOLIBRI 评分的主要相关因素是情绪状态（HADS 抑郁和焦虑）、功能状态（所需帮助的程度和 GOSE 的结果）和合并健康状况。这五个变量共同解释了总 QOLIBRI 评分的 58%。QOLIBRI 是第一个专门用于评估脑损伤特定疾病的 HRQoL 的工具，它包含了其他现有评估方法所没有的新信息。
