Santamarina-Pérez Pilar, Freniche Verónica, Eiroa-Orosa Francisco Jose, Llobet Guillem, Sáez Naia, Alegre José, Jacas Carlos
Servicio de Psiquiatría, Hospital Universitario Vall d'Hebron, Universitat Autònoma de Barcelona, España.
Med Clin (Barc). 2011 Mar 12;136(6):239-43. doi: 10.1016/j.medcli.2010.07.022. Epub 2010 Dec 9.
To analyze the role of depression in cognitive deficits of patients with chronic fatigue syndrome (CFS).
57 women with CFS were assessed by neuropsychological tests that included measures of attention: CalCap, Mental control of the WMS-III, PASAT, forward and backward digits (WAIS-III), symbol digit modalities test (SDMT); executive functions: Stroop Test, Trail Making Test (TMT A y B), FAS, Tower of London; memory: Auditory-Verbal Learning Test (AVL), Rey Complex Figure (RCF), and psychomotor skills: Grooved Pegboard. The raw scores on the tests were adjusted according to normative data and transformed to T scores. The sample was divided into two groups based on the presence or absence of depression, assessed by clinical interview and administration of the Hospital Anxiety and Depression Scale (HADS). This study compared neuropsychological test scores between the two groups.
CFS patients showed cognitive deficit in attention and executive functions, regardless of the presence of depression. There were no significant differences between the two CFS groups.
The cognitive impairments in patients with CFS are not secondary to the presence of depression. These results should be taken into account in the implementation of therapeutic programs in these patients.
分析抑郁症在慢性疲劳综合征（CFS）患者认知缺陷中的作用。
对57名患有CFS的女性进行神经心理学测试评估，这些测试包括注意力测量：CalCap、韦氏记忆量表第三版（WMS - III）的心理控制、连续加法测验（PASAT）、顺背和倒背数字广度（韦氏成人智力量表第三版，WAIS - III）、符号数字模式测验（SDMT）；执行功能：斯特鲁普测验、连线测验（TMT A和B）、FAS、伦敦塔测验；记忆：听觉言语学习测验（AVL）、雷氏复杂图形测验（RCF），以及心理运动技能：沟槽插板测验。测试的原始分数根据常模数据进行调整并转换为T分数。根据是否存在抑郁症将样本分为两组，通过临床访谈和使用医院焦虑抑郁量表（HADS）进行评估。本研究比较了两组之间的神经心理学测试分数。
无论是否存在抑郁症，CFS患者在注意力和执行功能方面均表现出认知缺陷。两组CFS患者之间无显著差异。
CFS患者的认知障碍并非由抑郁症所致。在为这些患者实施治疗方案时应考虑这些结果。
