GTPases 在细胞内运输中的作用概述。
GTPases in intracellular trafficking: an overview.
出版信息
Semin Cell Dev Biol. 2011 Feb;22(1):1-2. doi: 10.1016/j.semcdb.2010.12.004. Epub 2010 Dec 9.
Abstract
Small GTPases that belong to the ras sub-families of Rab, Arf, and Rho, and the large GTPase dynamin, regulate intracellular trafficking. This issue of Seminars of Cell and Developmental Biology highlights topics regarding mechanisms by which these GTPases regulate the different steps of vesicular transport: vesicle formation, scission, targeting and fusion. In addition, the emerging roles of GTPases in coordination of individual transport steps as well as coordination of intracellular trafficking with other cellular processes are reviewed. Finally, common structures and mechanisms underlying the function of the ras-like GTPases and the importance of their function to human health and disease are discussed.
摘要
属于 Ras 亚家族的小 GTPases（Rab、Arf 和 Rho）以及大 GTPase 动力蛋白调节细胞内运输。本期《细胞与发育生物学研讨会》重点介绍了这些 GTPases 调节囊泡运输不同步骤的机制：囊泡形成、分裂、靶向和融合。此外，还回顾了 GTPases 在协调单个运输步骤以及协调细胞内运输与其他细胞过程中的新兴作用。最后，讨论了 Ras 样 GTPases 功能的共同结构和机制及其对人类健康和疾病的重要性。
相似文献
1
GTPases in intracellular trafficking: an overview.GTPases 在细胞内运输中的作用概述。
Semin Cell Dev Biol. 2011 Feb;22(1):1-2. doi: 10.1016/j.semcdb.2010.12.004. Epub 2010 Dec 9.
2
Coordination of intracellular transport steps by GTPases.GTPases 对细胞内运输步骤的协调作用。
Semin Cell Dev Biol. 2011 Feb;22(1):33-8. doi: 10.1016/j.semcdb.2010.11.005. Epub 2010 Dec 2.
3
GTPases involved in vesicular trafficking: structures and mechanisms.参与囊泡运输的 GTPases：结构与机制。
Semin Cell Dev Biol. 2011 Feb;22(1):48-56. doi: 10.1016/j.semcdb.2010.10.003. Epub 2010 Oct 15.
4
Small GTPases controlling autophagy-related membrane traffic in yeast and metazoans.控制酵母和后生动物中自噬相关膜运输的小GTP酶。
Small GTPases. 2018 Nov 2;9(6):465-471. doi: 10.1080/21541248.2016.1258444. Epub 2016 Dec 22.
5
Small GTPases in vesicle trafficking.小GTP酶在囊泡运输中的作用
Curr Opin Plant Biol. 2004 Dec;7(6):694-700. doi: 10.1016/j.pbi.2004.09.014.
6
Roles of rho GTPases in intracellular transport and cellular transformation.Rho GTP酶在细胞内运输和细胞转化中的作用。
Int J Mol Sci. 2013 Mar 28;14(4):7089-108. doi: 10.3390/ijms14047089.
7
Small GTPases in plant biotic interactions.植物生物互作中的小GTP酶
Small GTPases. 2019 Sep;10(5):350-360. doi: 10.1080/21541248.2017.1333557. Epub 2017 Jun 23.
8
Membrane association and targeting of prenylated Ras-like GTPases.异戊二烯化的类Ras GTP酶的膜结合与靶向定位
Cell Signal. 1998 Mar;10(3):167-72. doi: 10.1016/s0898-6568(97)00120-4.
9
Molecular mechanisms of Sar/Arf GTPases in vesicular trafficking in yeast and plants.酵母和植物中 Sar/Arf GTPases 在囊泡运输中的分子机制。
Front Plant Sci. 2014 Aug 21;5:411. doi: 10.3389/fpls.2014.00411. eCollection 2014.
10
Rab GTPases in vesicular transport.囊泡运输中的Rab GTP酶。
Curr Opin Cell Biol. 1993 Aug;5(4):613-20. doi: 10.1016/0955-0674(93)90130-i.
引用本文的文献
1
Proximity interactome of lymphatic VE-cadherin reveals mechanisms of junctional remodeling and reelin secretion.淋巴管内皮 VE-钙黏蛋白的临近相互作用组揭示了连接重塑和 reelin 分泌的机制。
Nat Commun. 2024 Sep 4;15(1):7734. doi: 10.1038/s41467-024-51918-1.
2
Extracellular vesicle formation in is driven by a small GTPase.外泌体的形成是由一种小分子 GTP 酶驱动的。
Proc Natl Acad Sci U S A. 2024 Mar 5;121(10):e2311321121. doi: 10.1073/pnas.2311321121. Epub 2024 Feb 26.
3
Unveiling the Differences in Signaling and Regulatory Mechanisms between Dopamine D and D Receptors and Their Impact on Behavioral Sensitization.揭示多巴胺 D 和 D 受体在信号转导和调节机制方面的差异及其对行为敏化的影响。
Int J Mol Sci. 2023 Apr 4;24(7):6742. doi: 10.3390/ijms24076742.
4
RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1.RYR2/IRBIT 调节胰岛素瘤细胞系 INS-1 中的胰岛素基因转录物、胰岛素含量和分泌。
Sci Rep. 2022 May 11;12(1):7713. doi: 10.1038/s41598-022-11276-8.
5
Establishing Regulation of a Dynamic Process by Ypt/Rab GTPases : A Case for Cisternal Progression.Ypt/Rab GTP 酶对动态过程的调控机制：以潴泡进展为例
Methods Mol Biol. 2021;2293:189-199. doi: 10.1007/978-1-0716-1346-7_13.
6
Newer Methods Drive Recent Insights into Rab GTPase Biology: An Overview.新兴方法推动 Rab GTPase 生物学的最新见解：概述。
Methods Mol Biol. 2021;2293:1-18. doi: 10.1007/978-1-0716-1346-7_1.
7
Capturing membrane trafficking events during 3D angiogenic development in vitro.在体外三维血管生成发育过程中捕获膜运输事件。
Microcirculation. 2022 Oct;29(6-7):e12726. doi: 10.1111/micc.12726. Epub 2021 Aug 29.
8
Notch regulates vascular collagen IV basement membrane through modulation of lysyl hydroxylase 3 trafficking.Notch 通过调节赖氨酰羟化酶 3 的运输来调节血管胶原 IV 基底膜。
Angiogenesis. 2021 Nov;24(4):789-805. doi: 10.1007/s10456-021-09791-9. Epub 2021 May 6.
9
Rab1b and ARF5 are novel RNA-binding proteins involved in FMDV IRES-driven RNA localization.Rab1b 和 ARF5 是新型 RNA 结合蛋白，参与 FMDV IRES 驱动的 RNA 定位。
Life Sci Alliance. 2019 Jan 17;2(1). doi: 10.26508/lsa.201800131. Print 2019 Feb.
10
Two closely related Rho GTPases, Cdc42 and RacA, of the en-dophytic fungus Epichloë festucae have contrasting roles for ROS production and symbiotic infection synchronized with the host plant.内生真菌 Epichloë festucae 中的两个密切相关的 Rho GTPases，Cdc42 和 RacA，在与宿主植物同步的 ROS 产生和共生感染中发挥着相反的作用。
PLoS Pathog. 2018 Jan 25;14(1):e1006840. doi: 10.1371/journal.ppat.1006840. eCollection 2018 Jan.
本文引用的文献
1
Rab GTPases implicated in inherited and acquired disorders.Rab GTPases 参与遗传性和获得性疾病。
Semin Cell Dev Biol. 2011 Feb;22(1):57-68. doi: 10.1016/j.semcdb.2010.12.005. Epub 2010 Dec 13.
2
Rho GTPases and exocytosis: what are the molecular links?Rho GTPases 和胞吐作用：分子联系是什么？
Semin Cell Dev Biol. 2011 Feb;22(1):27-32. doi: 10.1016/j.semcdb.2010.12.002. Epub 2010 Dec 8.
3
Coordination of intracellular transport steps by GTPases.GTPases 对细胞内运输步骤的协调作用。
Semin Cell Dev Biol. 2011 Feb;22(1):33-8. doi: 10.1016/j.semcdb.2010.11.005. Epub 2010 Dec 2.
4
GTPases involved in vesicular trafficking: structures and mechanisms.参与囊泡运输的 GTPases：结构与机制。
Semin Cell Dev Biol. 2011 Feb;22(1):48-56. doi: 10.1016/j.semcdb.2010.10.003. Epub 2010 Oct 15.
5
Vesicle scission: dynamin.囊泡分裂：动力蛋白。
Semin Cell Dev Biol. 2011 Feb;22(1):10-7. doi: 10.1016/j.semcdb.2010.09.001. Epub 2010 Sep 15.
6
ARF6-mediated endocytic recycling impacts cell movement, cell division and lipid homeostasis.ARF6 介导向内体再循环影响细胞运动、细胞分裂和脂质动态平衡。
Semin Cell Dev Biol. 2011 Feb;22(1):39-47. doi: 10.1016/j.semcdb.2010.09.002. Epub 2010 Sep 15.
7
New links between vesicle coats and Rab-mediated vesicle targeting.囊泡包被与 Rab 介导的囊泡靶向之间的新联系。
Semin Cell Dev Biol. 2011 Feb;22(1):18-26. doi: 10.1016/j.semcdb.2010.07.003. Epub 2010 Jul 17.
8
Models for the functions of Arf GAPs.Arf GAP 功能模型。
Semin Cell Dev Biol. 2011 Feb;22(1):3-9. doi: 10.1016/j.semcdb.2010.07.002. Epub 2010 Jul 15.
9
The small G proteins of the Arf family and their regulators.Arf家族的小G蛋白及其调节因子。
Annu Rev Cell Dev Biol. 2007;23:579-611. doi: 10.1146/annurev.cellbio.23.090506.123209.
10
Rho GTPases: biochemistry and biology.Rho 鸟苷三磷酸酶：生物化学与生物学
Annu Rev Cell Dev Biol. 2005;21:247-69. doi: 10.1146/annurev.cellbio.21.020604.150721.
Zotero 插件