火木层孔菌的内多糖通过增强细胞介导的免疫来发挥抗肿瘤作用。
Endo-polysaccharide of Phellinus igniarius exhibited anti-tumor effect through enhancement of cell mediated immunity.
机构信息
College of Chinese Medicinal Materials, Jilin Agricultural University Changchun, Jilin, 130118 PR China.
出版信息
Int Immunopharmacol. 2011 Feb;11(2):255-9. doi: 10.1016/j.intimp.2010.11.033. Epub 2010 Dec 9.
The purpose of this study was to assess the anti-tumor and immunomodulatory effects of PIE on tumor cells Sarcoma 180 and Hepatoma 22 in implanted mice. The monosaccharide composition of PIE was analyzed by GC. The results demonstrated that PIE monosaccharide composition was n(Xyl): n(Man): n(Fuc): n(Glc): n(Gal)=2.3: 1: 6.4: 22.1: 19.83. The oral administration of PIE characteristically inhibited the growth of S180 and H22 cells and increased the life span. The concentrations of serum IL-2 and IL-18 were significantly increased in the S180 implanted mice fed with PIE in the doses of 500 mg/kg and 250 mg/kg compared with those in control (p<0.01). The concentrations of serum IL-2 were significantly increased in H22 implanted mice in the doses of 500 mg/kg and 250 mg/kg compared with those in control (p<0.01).
本研究旨在评估 PIE 在植入小鼠的肉瘤 180 和肝癌 22 细胞中的抗肿瘤和免疫调节作用。通过 GC 分析 PIE 的单糖组成。结果表明，PIE 单糖组成的摩尔比为 n（Xyl）：n（Man）：n（Fuc）：n（Glc）：n（Gal）=2.3：1：6.4：22.1：19.83。PIE 的口服给药显著抑制了 S180 和 H22 细胞的生长并延长了寿命。与对照组相比，在剂量为 500mg/kg 和 250mg/kg 时，喂食 PIE 的 S180 荷瘤小鼠血清中 IL-2 和 IL-18 的浓度显著增加（p<0.01）。在剂量为 500mg/kg 和 250mg/kg 时，H22 荷瘤小鼠血清中 IL-2 的浓度与对照组相比显著增加（p<0.01）。
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