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人类胚胎碎片化的发病机制、发育后果和临床相关性。

Pathogenesis, developmental consequences, and clinical correlations of human embryo fragmentation.

机构信息

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, California 94115-0916, USA.

出版信息

Fertil Steril. 2011 Mar 15;95(4):1197-204. doi: 10.1016/j.fertnstert.2010.11.033. Epub 2010 Dec 13.

DOI:10.1016/j.fertnstert.2010.11.033
PMID:21146166
Abstract

This narrative review summarizes the current state of knowledge about human embryo fragmentation during IVF. The clinical relevance of fragmentation is discussed and evidence supporting a central role for the oocyte in the pathogenesis of fragmentation is presented. A mechanism of fragmentation as aberrant cell division involving the cytoskeleton is described along with the novel concept of membrane instability in relation to follicular high-density lipoprotein metabolism and cholesterol transport.

摘要

这篇叙述性评论总结了目前关于体外受精过程中人类胚胎碎片化的知识状况。讨论了碎片化的临床相关性，并提出了支持卵母细胞在碎片化发病机制中起核心作用的证据。描述了碎片化作为涉及细胞骨架的异常细胞分裂的一种机制，以及与卵泡高密度脂蛋白代谢和胆固醇转运有关的膜不稳定的新概念。

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